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Mouse Anti-CNOT6 Recombinant Antibody (2193C2a) (CBMAB-C0654-LY)

This product is antibody recognizes CNOT6. The antibody 2193C2a immunoassay techniques such as: DB.
See all CNOT6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2193C2a
Antibody Isotype
IgG2b
Application
DB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
1% BSA
Preservative
0.05% sodium azide
Concentration
0.1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CCR4-NOT Transcription Complex Subunit 6
Introduction
CNOT6 (CCR4-NOT Transcription Complex Subunit 6) is a Protein Coding gene. Among its related pathways are Gene Expression and Deadenylation-dependent mRNA decay. Gene Ontology (GO) annotations related to this gene include RNA binding and poly(A)-specific ribonuclease activity. An important paralog of this gene is CNOT6L.
Entrez Gene ID
57472
UniProt ID
Q9ULM6
Alternative Names
CCR4-NOT Transcription Complex Subunit 6; Carbon Catabolite Repressor Protein 4 Homolog; Cytoplasmic Deadenylase; EC 3.1.13.4; Ccr4a; CCR4;
Function
Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence.
Biological Process
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
Exonucleolytic catabolism of deadenylated mRNA Source: UniProtKB
Gene silencing by miRNA Source: UniProtKB
Nuclear-transcribed mRNA catabolic process, no-go decay Source: UniProtKB
Nuclear-transcribed mRNA poly(A) tail shortening Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of cytoplasmic mRNA processing body assembly Source: UniProtKB
Regulation of translation Source: UniProtKB-KW
Cellular Location
Cytoplasm; Nucleus. Predominantly cytoplasmic.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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