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Rabbit Anti-CNTN5 Recombinant Antibody (024) (CBMAB-C1685-LY)

This product is antibody recognizes CNTN5. The antibody 024 immunoassay techniques such as: ELISA(Cap).
See all CNTN5 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
024
Antibody Isotype
IgG
Application
ELISA(Cap)

Basic Information

Immunogen
Recombinant Human Contactin 5 / CNTN5 Protein
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Contactin 5
Introduction
CNTN5 (Contactin 5) is a Protein Coding gene. Diseases associated with CNTN5 include Actinomycosis. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins.

An important paralog of this gene is CNTN3.
Entrez Gene ID
53942
UniProt ID
O94779
Alternative Names
Contactin 5; Neural Recognition Molecule NB-2; Neural Adhesion Molecule; Contactin-5; HNB-2s; HNB-2; NB-2;
Function
Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons. Probably involved in neuronal activity in the auditory system (By similarity).
Biological Process
Cell adhesion Source: UniProtKB-KW
Presynapse assembly Source: Ensembl
Sensory perception of sound Source: Ensembl
Cellular Location
Cell membrane

Schmilovich, Z., Huguet, G., He, Q., Musa-Johnson, A., Douard, E., Loum, M. A., ... & Rouleau, G. A. (2021). Copy-Number Variants in The Contactin-5 Gene Are a Potential Risk Factor for Autism Spectrum Disorder.

Dauar, M. T., Picard, C., Rosa‐Neto, P., Villeneuve, S., Poirier, J., & Prevent‐AD Research Group. (2021). CNTN5 is associated with disease risk and pathology throughout the Alzheimer’s disease continuum. Alzheimer's & Dementia, 17, e052359.

Kleijer, K. T., van Nieuwenhuize, D., Spierenburg, H. A., Gregorio-Jordan, S., Kas, M. J., & Burbach, J. P. H. (2018). Structural abnormalities in the primary somatosensory cortex and a normal behavioral profile in Contactin-5 deficient mice. Cell Adhesion & Migration, 12(1), 5-18.

Smirnov, A. V., Kontsevaya, G. V., Feofanova, N. A., Anisimova, M. V., Serova, I. A., Gerlinskaya, L. A., ... & Serov, O. L. (2018). Unexpected phenotypic effects of a transgene integration causing a knockout of the endogenous Contactin-5 gene in mice. Transgenic research, 27(1), 1-13.

Peng, Y. R., Tran, N. M., Krishnaswamy, A., Kostadinov, D., Martersteck, E. M., & Sanes, J. R. (2017). Satb1 regulates contactin 5 to pattern dendrites of a mammalian retinal ganglion cell. Neuron, 95(4), 869-883.

Oguro-Ando, A., Zuko, A., Kleijer, K. T., & Burbach, J. P. H. (2017). A current view on contactin-4,-5, and-6: Implications in neurodevelopmental disorders. Molecular and Cellular Neuroscience, 81, 72-83.

Smirnov, A. V., Feofanova, N. A., Kontsevaya, G. V., Anisimova, M. V., Kovrigin, I. I., Serova, I. A., ... & Battulin, N. R. (2017). Morphophysiological effects of insertional mutagenesis of the contactin 5 (Cntn5) gene in transgenic mice. Russian Journal of Genetics: Applied Research, 7(8), 799-805.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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