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Mouse Anti-COG4 Recombinant Antibody (CBXC-0499) (CBMAB-C5751-CQ)

This product is a mouse antibody that recognizes COG4. The antibody CBXC-0499 can be used for immunoassay techniques such as: ELISA.
See all COG4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-0499
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
component of oligomeric golgi complex 4
Introduction
COG4 (Component Of Oligomeric Golgi Complex 4) is a Protein Coding gene. Diseases associated with COG4 include Congenital Disorder Of Glycosylation, Type Iij and Congenital Disorder Of Glycosylation, Type Ii. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism of proteins.
Entrez Gene ID
25839
UniProt ID
Q9H9E3
Alternative Names
Component Of Oligomeric Golgi Complex 4; COG Complex Subunit 4; Conserved Oligomeric Golgi Complex Protein 4; Conserved Oligomeric Golgi Complex Subunit 4; Complexed With Dor1p; CDG2J; COD1;
Function
Required for normal Golgi function (PubMed:19536132, PubMed:30290151).

Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1 (PubMed:19536132).
Biological Process
Endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
Golgi organization Source: UniProtKB
Golgi vesicle prefusion complex stabilization Source: UniProtKB
Protein transport Source: UniProtKB-KW
Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Source: UniProtKB
Cellular Location
Cytosol; Golgi apparatus membrane. Mosty cytosolic, with about 5% membrane-bound.
Involvement in disease
Congenital disorder of glycosylation 2J (CDG2J):
A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.
Saul-Wilson syndrome (SWILS):
A rare skeletal dysplasia with characteristic dysmorphic and radiographic findings, as well as early developmental delay, primarily involving speech, with eventual normal cognition. Clinical findings include marked short stature, prominent forehead with an enlarged anterior fontanel, prominent eyes with cataracts, narrow nasal bridge with a convex nasal ridge, micrognathia, clubfoot, brachydactyly, and short distal phalanges of fingers. Radiographic changes include platyspondyly, irregular end plates of vertebral bodies, and hypoplasia of the odontoid process with cervical instability in the spine, coxa valga, overtubulation, metaphyseal flaring and megaepiphyses in the long bones, while the hands and feet exhibit short phalanges, metacarpals and metatarsals, cone-shaped epiphyses of phalanges, and accessory ossification centers of metacarpals and metatarsals.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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