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Mouse Anti-COL13A1 Recombinant Antibody (CBXC-1257) (CBMAB-C1524-CQ)

This product is a mouse antibody that recognizes COL13A1. The antibody CBXC-1257 can be used for immunoassay techniques such as: IHC.
See all COL13A1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-1257
Antibody Isotype
IgG2b
Application
IHC

Basic Information

Immunogen
CHO-derived recombinant human Collagen XIII alpha 1, Glu109-Pro668, Accession # Q5TAT6
Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
Lyophilized from PBS
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Collagen Type XIII Alpha 1 Chain
Introduction
COL13A1 (Collagen Type XIII Alpha 1 Chain) is a Protein Coding gene. Diseases associated with COL13A1 include Myasthenic Syndrome, Congenital, 19 and Postsynaptic Congenital Myasthenic Syndromes. Among its related pathways are Integrin Pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include heparin binding. An important paralog of this gene is COL23A1.
Entrez Gene ID
1305
UniProt ID
Q5TAT6
Alternative Names
Collagen Type XIII Alpha 1 Chain; Collagen, Type XIII, Alpha 1; COLXIIIA1; Collagen Alpha-1(XIII) Chain; CMS19;
Function
Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin. At neuromuscular junctions, may play a role in acetylcholine receptor clustering (PubMed:26626625).
Biological Process
Cell-cell adhesion Source: UniProtKB
Cell differentiation Source: UniProtKB-KW
Cell-matrix adhesion Source: UniProtKB
Collagen catabolic process Source: Reactome
Collagen fibril organization Source: GO_Central
Endochondral ossification Source: UniProtKB
Extracellular matrix organization Source: GO_Central
Morphogenesis of a branching structure Source: UniProtKB
Notochord development Source: GO_Central
Skeletal system development Source: GO_Central
Cellular Location
Cell membrane; Postsynaptic cell membrane
Involvement in disease
Myasthenic syndrome, congenital, 19 (CMS19):
A form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features are easy fatigability and muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort.
Topology
Cytoplasmic: 1-44
Helical: 45-61
Extracellular: 62-717
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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