Rabbit Anti-COL19A1 Recombinant Antibody (EG765) (CBMAB-EN920-LY)

The product is antibody recognizes COL19A1. The antibody EG765 immunoassay techniques such as: IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:1000.
See all COL19A1 antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human

Clone

EG765

Antibody Isotype

IgG

Application

IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:1000

Basic Information

Immunogen

The antibody was produced against synthesized peptide derived from internal of human Collagen XIX α1.

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Collagen Type XIX Alpha 1 Chain

Introduction

COL19A1 (Collagen Type XIX Alpha 1 Chain) is a Protein Coding gene. Among its related pathways are Integrin Pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include extracellular matrix structural constituent and protein binding, bridging. An important paralog of this gene is COL22A1.

Entrez Gene ID

1310

UniProt ID

Q14993

Alternative Names

Collagen Type XIX Alpha 1 Chain; Collagen, Type XIX, Alpha 1; Collagen XIX, Alpha-1 Polypeptide; A1 Chain Of Type XIX Collagen; Collagen Alpha-1(XIX) Chain; Collagen Alpha 1 (Y) Chain; Collagen Alpha-1(Y) Chain; COL9A1L; D6S228E;

Function

May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the sphinteric smooth muscle.

Biological Process

Cell adhesion Source: UniProtKB
Cell-cell adhesion Source: UniProtKB
Cell differentiation Source: UniProtKB-KW
Collagen catabolic process Source: Reactome
Collagen fibril organization Source: Reactome
Extracellular matrix organization Source: GO_Central
Skeletal muscle tissue development Source: Ensembl
Skeletal system development Source: ProtInc

Cellular Location

Extracellular matrix

PTM

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

References

Sato, H., Jin, K., Yano, S., Yasuda, A., Adachi, S., Yoshioka, H., ... & Sasaki, T. (2022). Abnormalities in esophageal smooth muscle induced by mutations in collagen XIX. Histochemistry and Cell Biology, 1-12.

Calvo, A. C., Moreno, L., Moreno, L., Toivonen, J. M., Manzano, R., Molina, N., ... & Osta, R. (2020). Type XIX collagen: a promising biomarker from the basement membranes. Neural Regeneration Research, 15(6), 988.

Thorlacius-Ussing, J., Manon-Jensen, T., Sun, S., Leeming, D. J., Sand, J. M., Karsdal, M., & Willumsen, N. (2020). Serum type XIX collagen is significantly elevated in non-small cell lung cancer: a preliminary study on biomarker potential. Cancers, 12(6), 1510.

Calvo, A. C., Cibreiro, G. A., Merino, P. T., Roy, J. F., Galiana, A., Rufián, A. J., ... & Redondo, A. G. (2019). Collagen XIX alpha 1 improves prognosis in amyotrophic lateral sclerosis. Aging and disease, 10(2), 278.

Oudart, J. B., Monboisse, J. C., Maquart, F. X., Brassart, B., Brassart-Pasco, S., & Ramont, L. (2017). Type XIX collagen: A new partner in the interactions between tumor cells and their microenvironment. Matrix Biology, 57, 169-177.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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