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Rabbit Anti-COL4A5 Recombinant Antibody (EG771) (CBMAB-EN926-LY)

The product is antibody recognizes COL4A5. The antibody EG771 immunoassay techniques such as: IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:10000.
See all COL4A5 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
EG771
Antibody Isotype
IgG
Application
IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:10000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human Collagen IV α5.
Specificity
Human, Mouse
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Collagen Type IV Alpha 5 Chain
Introduction
COL4A5 (Collagen Type IV Alpha 5 Chain) is a Protein Coding gene. Diseases associated with COL4A5 include Alport Syndrome, X-Linked and Hypertension, Early-Onset, Autosomal Dominant, With Severe Exacerbation In Pregnancy. Among its related pathways are Primary Focal Segmental Glomerulosclerosis FSGS and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include extracellular matrix structural constituent. An important paralog of this gene is COL4A1.
Entrez Gene ID
Human1287
Mouse12830
UniProt ID
HumanP29400
MouseQ63ZW6
Alternative Names
Collagen Type IV Alpha 5 Chain; Collagen, Type IV, Alpha 5; Collagen Of Basement Membrane, Alpha-5 Chain; Collagen IV, Alpha-5 Polypeptide; Collagen Alpha-5(IV) Chain; Collagen Type IV Alpha 5; Alport Syndrome;
Function
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
Biological Process
Collagen-activated tyrosine kinase receptor signaling pathway Source: Ensembl
Collagen fibril organization Source: Reactome
Extracellular matrix organization Source: GO_Central
Neuromuscular junction development Source: Ensembl
Cellular Location
Basement membrane
Involvement in disease
Alport syndrome 1, X-linked (ATS1):
A syndrome that is characterized by progressive glomerulonephritis, renal failure, sensorineural deafness, specific eye abnormalities (lenticonous and macular flecks), and glomerular basement membrane defects. The disorder shows considerable heterogeneity in that families differ in the age of end-stage renal disease and the occurrence of deafness.
PTM
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens.
The trimeric structure of the NC1 domains is stabilized by covalent bonds between Lys and Met residues.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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