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Mouse Anti-COL5A2 Recombinant Antibody (3G11) (CBMAB-C6107-LY)

This product is antibody recognizes COL5A2. The antibody 3G11 immunoassay techniques such as: ELISA, WB.
See all COL5A2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3G11
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Collagen Type V Alpha 2 Chain
Introduction
COL5A2 (Collagen Type V Alpha 2 Chain) is a Protein Coding gene. Diseases associated with COL5A2 include Ehlers-Danlos Syndrome Type 2 and Ehlers-Danlos Syndrome, Classic Type, 2. Among its related pathways are Integrin Pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include extracellular matrix structural constituent and SMAD binding.
An important paralog of this gene is COL2A1.
Entrez Gene ID
1290
UniProt ID
P05997
Alternative Names
Collagen Type V Alpha 2 Chain; AB Collagen; Collagen, Fetal Membrane, A Polypeptide; Type V Preprocollagen Alpha 2 Chain; Collagen, Type V, Alpha 2; Collagen Alpha-2(V) Chain; EDSCL2; EDSC;
Function
Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue-specific matrices (By similarity).
Biological Process
Cellular response to amino acid stimulus Source: Ensembl
Collagen fibril organization Source: UniProtKB
Extracellular matrix organization Source: GO_Central
Eye morphogenesis Source: UniProtKB
Negative regulation of endodermal cell differentiation Source: UniProtKB
Ossification Source: Ensembl
Skeletal system development Source: Ensembl
Skin development Source: UniProtKB
Cellular Location
Extracellular matrix
Involvement in disease
Ehlers-Danlos syndrome, classic type, 2 (EDSCL2):
A form of Ehlers-Danlos syndrome, a group of connective tissue disorders characterized by skin hyperextensibility, articular hypermobility, and tissue fragility. The main features of classic Ehlers-Danlos syndrome are joint hypermobility and dislocation, and fragile, bruisable skin. EDSCL2 inheritance is autosomal dominant.
PTM
Prolines at the third position of the tripeptide repeating unit (G-X-P) are hydroxylated in some or all of the chains. Probably 3-hydroxylated on Pro-919 and Pro-1156 by LEPREL1.

Mamoor, S. (2021). COL5A2 is differentially expressed in lymph node metastasis in human breast cancer.

Ilieș, R. F., Aioanei, C. S., Cătană, A., Halmagyi, S. R., Lukacs, I., Tokes, R. E., ... & Pop, I. V. (2021). Involvement of COL5A2 and TGF‑β1 in pathological scarring. Experimental and Therapeutic Medicine, 22(4), 1-4.

Chen, H. C., Tseng, Y. K., Shu, C. W., Weng, T. J., Liou, H. H., Yen, L. M., ... & Liu, P. F. (2019). Differential clinical significance of COL 5A1 and COL 5A2 in tongue squamous cell carcinoma. Journal of Oral Pathology & Medicine, 48(6), 468-476.

Dong, Y., Yang, L., Luo, W., Zhu, T., Yan, W., Kong, J., ... & Zhao, Q. (2019). Mannose receptor C type 2 mediates 1, 25 (OH) 2D3/vitamin D receptor-regulated collagen metabolism through collagen type 5, alpha 2 chain and matrix metalloproteinase 13 in murine MC3T3-E1 cells. Molecular and cellular endocrinology, 483, 74-86.

Meng, X. Y., Shi, M. J., Zeng, Z. H., Chen, C., Liu, T. Z., Wu, Q. J., ... & Li, S. (2019). The role of COL5A2 in patients with muscle-invasive bladder cancer: a bioinformatics analysis of public datasets involving 787 subjects and 29 cell lines. Frontiers in Oncology, 8, 659.

Zeng, X. T., Liu, X. P., Liu, T. Z., & Wang, X. H. (2018). The clinical significance of COL5A2 in patients with bladder cancer: A retrospective analysis of bladder cancer gene expression data. Medicine, 97(10).

Yang, F., Luo, P., Ding, H., Zhang, C., & Zhu, Z. (2018). Collagen type V a2 (COL5A2) is decreased in steroid-induced necrosis of the femoral head. American Journal of Translational Research, 10(8), 2469.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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