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Mouse Anti-COL8A2 Recombinant Antibody (CBFYC-2083) (CBMAB-C2149-FY)

This product is mouse antibody that recognizes COL8A2. The antibody CBFYC-2083 can be used for immunoassay techniques such as: ELISA, WB.
See all COL8A2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-2083
Antibody Isotype
IgG2a, k
Application
ELISA, WB

Basic Information

Immunogen
COL8A2 (NP_005193.1, 626 a.a.-696 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: VHVKGTNVWV ALYKNNVPAT YTYDEYKKGY LDQASGGAVL QLRPNDQVWV QMPSDQANGL YSTEYIHSSF S
Specificity
Human
Antibody Isotype
IgG2a, k
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
collagen, type VIII, alpha 2
Introduction
COL8A2 (Collagen Type VIII Alpha 2 Chain) is a Protein Coding gene. Diseases associated with COL8A2 include Corneal Dystrophy, Posterior Polymorphous, 2 and Corneal Dystrophy, Fuchs Endothelial, 1. Among its related pathways are Integrin Pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include extracellular matrix structural constituent and protein binding, bridging. An important paralog of this gene is COL8A1.
Entrez Gene ID
1296
UniProt ID
P25067
Alternative Names
Collagen Type VIII Alpha 2 Chain; Collagen, Type VIII, Alpha 2; Endothelial Collagen; Collagen VIII, Alpha-2 Polypeptide; Collagen Alpha-2(VIII) Chain; Collagen Type VIII Alpha 2
Function
Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity).
Biological Process
Angiogenesis Source: UniProtKB-KW
Camera-type eye morphogenesis Source: Ensembl
Cell-cell adhesion Source: UniProtKB
Collagen fibril organization Source: Reactome
Epithelial cell proliferation Source: Ensembl
Extracellular matrix organization Source: GO_Central
Cellular Location
Basement membrane
Involvement in disease
Corneal dystrophy, Fuchs endothelial, 1 (FECD1):
A corneal disease caused by loss of endothelium of the central cornea. It is characterized by focal wart-like guttata that arise from Descemet membrane and develop in the central cornea, epithelial blisters, reduced vision and pain. Descemet membrane is thickened by abnormal collagenous deposition.
Corneal dystrophy, posterior polymorphous, 2 (PPCD2):
A rare mild subtype of posterior corneal dystrophy characterized by alterations of Descemet membrane presenting as vesicles, opacities or band-like lesions on slit-lamp examination and specular microscopy. Affected patient typically are asymptomatic.
PTM
Proteolytically cleaved by neutrophil elastase, in vitro.
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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