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Mouse Anti-COMMD10 Recombinant Antibody (CBWJC-2945) (CBMAB-C4089WJ)

This product is a Mouse antibody that recognizes COMMD10. This antibody CBWJC-2945 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all COMMD10 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJC-2945
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
COMM Domain Containing 10
Introduction
COMMD10 (COMM Domain Containing 10) is a Protein Coding gene.
Entrez Gene ID
51397
UniProt ID
Q9Y6G5
Alternative Names
COMM Domain Containing 10; COMM Domain-Containing Protein 10; PTD002;
Function
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237).

May down-regulate activation of NF-kappa-B (PubMed:15799966).
Cellular Location
Cytoplasm; Nucleus

Yang, M., Wu, X., Li, L., Li, S., Li, N., Mao, M., ... & Guan, J. (2021). COMMD10 inhibits tumor progression and induces apoptosis by blocking NF‐κB signal and values up BCLC staging in predicting overall survival in hepatocellular carcinoma. Clinical and translational medicine, 11(5), e403.

Cohen, K., Mouhadeb, O., Shlomo, S. B., Langer, M., Neumann, A., Erez, N., ... & Varol, C. (2021). COMMD10 is critical for Kupffer cell survival and controls Ly6Chi monocyte differentiation and inflammation in the injured liver. Cell reports, 37(7), 110026.

Fan, Y., Zhang, L., Sun, Y., Yang, M., Wang, X., Wu, X., ... & Guan, J. (2020). Expression profile and bioinformatics analysis of COMMD10 in BALB/C mice and human. Cancer gene therapy, 27(3), 216-225.

Rasulov, S. (2020). COMMD10 in epithelial sodium channel (ENaC) trafficking (Doctoral dissertation, University of Otago).

Yang, M., Wu, X., Li, L., Li, S., Pan, S., Du, R., ... & Guan, J. (2019). Inflammation-Related Biomarker COMMD10 Values Up BCLC Staging in Individualized Prediction of Overall Survival in Hepatocellular Carcinoma.

Ware, A. W., Cheung, T. T., Rasulov, S., Burstein, E., & McDonald, F. J. (2018). Epithelial Na+ channel: reciprocal control by COMMD10 and Nedd4-2. Frontiers in Physiology, 9, 793.

Yang, S. S., Li, X. M., Yang, M., Ren, X. L., Hu, J. L., Zhu, X. H., ... & Liang, L. (2017). FMNL2 destabilises COMMD10 to activate NF-κB pathway in invasion and metastasis of colorectal cancer. British journal of cancer, 117(8), 1164-1175.

Ware, A. W. (2017). COMMD10 regulates protein trafficking (Doctoral dissertation, University of Otago).

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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