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Mouse Anti-COPS6 Recombinant Antibody (40000000) (CBMAB-C0593-YY)

This product is mouse antibody that recognizes COPS6. The antibody 40000000 can be used for immunoassay techniques such as: WB, IHC-P, IF
See all COPS6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
40000000
Antibody Isotype
IgG2a
Application
WB, IHC-P, IF

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Protein A purified
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)
Entrez Gene ID
10980
UniProt ID
Q7L5N1
Alternative Names
COBW Domain Containing 1; Cobalamin Synthase W Domain-Containing Protein 1; NPC-A-6 COBW Domain-Containing Protein 1; COBP; Cobalamin Synthetase W Domain-Containing Protein 1; COBW Domain-Containing Protein 1; COBW-Like Protein; NPC-A-6;
Function
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity. Stabilizes COP1 through reducing COP1 auto-ubiquitination and decelerating COP1 turnover rate, hence regulates the ubiquitination of COP1 targets.
Biological Process
Nucleotide-excision repair, DNA damage recognition Source: Reactome
Post-translational protein modification Source: Reactome
Protein deneddylation Source: UniProtKB
Transcription-coupled nucleotide-excision repair Source: Reactome
Viral process Source: UniProtKB-KW
Cellular Location
Nucleus; Cytoplasm; Perinuclear region. (Microbial infection) The interaction with HIV-1 Vpr protein possibly leads its translocation to a perinuclear region.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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