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Rabbit Anti-COPS7B Recombinant Antibody (EPR6464) (CBMAB-1417-CN)

This product is a rabbit antibody that recognizes COPS7B of human. The antibody EPR6464 can be used for immunoassay techniques such as: WB, IHC-P, IF, FC.
See all COPS7B antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EPR6464
Antibody Isotype
IgG
Application
WB, IHC-P, IF, FC

Basic Information

Immunogen
Synthetic peptide corresponding to residues in Human CSN7b.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% Glycerol, 0.05% BSA, pH 7.4
Preservative
0.01% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
COP9 Signalosome Subunit 7B
Introduction
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Entrez Gene ID
Human64708
Mouse26895
Rat363273
UniProt ID
HumanQ9H9Q2
MouseQ8BV13
RatP61203
Alternative Names
CSN7B; SGN7b
Function
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Biological Process
COP9 signalosome assembly Source: InterPro
Nucleotide-excision repair, DNA damage recognition Source: Reactome
Post-translational protein modification Source: Reactome
Protein deneddylation Source: UniProtKB
Transcription-coupled nucleotide-excision repair Source: Reactome
Viral process Source: UniProtKB-KW
Cellular Location
Cytoplasm; Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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