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Mouse Anti-CORO1C Recombinant Antibody (1F7) (CBMAB-C4079-LY)

This product is antibody recognizes CORO1C. The antibody 1F7 immunoassay techniques such as: ELISA, WB, IHC-P.
See all CORO1C antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1F7
Antibody Isotype
IgG2a, κ
Application
ELISA, WB, IHC-P

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
coronin, actin binding protein, 1C
Introduction
CORO1C (Coronin 1C) is a Protein Coding gene. Diseases associated with CORO1C include Coronin-1A Deficiency. Gene Ontology (GO) annotations related to this gene include actin filament binding. An important paralog of this gene is CORO1B.
Entrez Gene ID
23603
UniProt ID
Q9ULV4
Alternative Names
Coronin 1C; Coronin-3; HCRNN4; Coronin, Actin-Binding Protein, 1C; Coronin, Actin Binding Protein, 1C; Coronin-1C; CRNN4; CRN2;
Function
Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (PubMed:25074804, PubMed:25925950).

Increases the presence of activated RAC1 at the leading edge of migrating cells (PubMed:25074804, PubMed:25925950).

Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments (By similarity).

Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460).

Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460).

Required for normal cell proliferation, cell migration, and normal formation of lamellipodia (By similarity).

Required for normal distribution of mitochondria within cells (By similarity).

Isoform 3:
Involved in myogenic differentiation.
Biological Process
Actin filament organization Source: GO_Central
Activation of GTPase activity Source: UniProtKB
Cell migration Source: GO_Central
Endosomal transport Source: UniProtKB
Endosome fission Source: UniProtKB
Endosome membrane tubulation Source: UniProtKB
Establishment of protein localization Source: UniProtKB
Membrane fission Source: UniProtKB
Negative regulation of epithelial cell migration Source: UniProtKB
Negative regulation of focal adhesion assembly Source: UniProtKB
Negative regulation of protein kinase activity by regulation of protein phosphorylation Source: UniProtKB
Negative regulation of protein phosphorylation Source: UniProtKB
Negative regulation of substrate adhesion-dependent cell spreading Source: UniProtKB
Neural crest cell migration Source: UniProtKB
Phagocytosis Source: ProtInc
Positive regulation of lamellipodium morphogenesis Source: UniProtKB
Regulation of epithelial cell migration Source: UniProtKB
Regulation of fibroblast migration Source: UniProtKB
Regulation of focal adhesion assembly Source: UniProtKB
Regulation of protein phosphorylation Source: UniProtKB
Regulation of ruffle assembly Source: Ensembl
Regulation of substrate adhesion-dependent cell spreading Source: UniProtKB
Signal transduction Source: ProtInc
Cellular Location
Cytoskeleton; Endosome membrane; Cell membrane; Ruffle membrane; Lamellipodium; Cell cortex. All isoforms colocalize with the actin cytoskeleton in the cytosol, and especially in the cell cortex (PubMed:10828594, PubMed:19651142, PubMed:25074804). Colocalizes with F-actin at the leading edge of lamellipodia. Partially colocalizes with microtubules and vimentin intermediate filaments (PubMed:10828594, PubMed:19651142, PubMed:25074804). Localizes to endosome membrane tubules/buds (PubMed:30220460).
Isoform 3: Cytoskeleton; Sarcolemma; Cell membrane; Sarcomere; Synapse; Cell cortex. Colocalizes with the thin filaments of the sarcomere and with the postsynaptic area and the junctional sarcoplasm of motor end plates. Colocalizes with the actin cytoskeleton in the cytosol, and especially in the cell cortex.

Li, J., Tian, L., Jing, Z., Guo, Z., Nan, P., Liu, F., ... & Zhao, X. (2021). Cytoplasmic RAD23B interacts with CORO1C to synergistically promote colorectal cancer progression and metastasis. Cancer Letters, 516, 13-27.

Zhang, W., Song, C., & Ren, X. (2021). Circ_0003998 regulates the progression and docetaxel sensitivity of DTX-resistant non-small cell lung cancer cells by the miR-136-5p/CORO1C axis. Technology in cancer research & treatment, 20, 1533033821990040.

Wang, Z., & Jia, L. (2021). CORO1C is Associated With Poor Prognosis and Promotes Metastasis Through PI3K/AKT Pathway in Colorectal Cancer. Frontiers in molecular biosciences, 8.

Liao, M., & Peng, L. (2020). MiR-206 may suppress non-small lung cancer metastasis by targeting CORO1C. Cellular & molecular biology letters, 25(1), 1-13.

Han, S., Ding, X., Wang, S., Xu, L., Li, W., & Sun, W. (2020). miR-133a-3p regulates hepatocellular carcinoma progression through targeting CORO1C. Cancer Management and Research, 12, 8685.

Li, Q., Dai, Z., Xia, C., Jin, L., & Chen, X. (2020). Suppression of long non-coding RNA MALAT1 inhibits survival and metastasis of esophagus cancer cells by sponging miR-1-3p/CORO1C/TPM3 axis. Molecular and Cellular Biochemistry, 470(1), 165-174.

Tagliatela, A. C., Hempstead, S. C., Hibshman, P. S., Hockenberry, M. A., Brighton, H. E., Pecot, C. V., & Bear, J. E. (2020). Coronin 1C inhibits melanoma metastasis through regulation of MT1-MMP-containing extracellular vesicle secretion. Scientific reports, 10(1), 1-16.

Castagnino, A., Castro-Castro, A., Irondelle, M., Guichard, A., Lodillinsky, C., Fuhrmann, L., ... & Chavrier, P. (2018). Coronin 1C promotes triple-negative breast cancer invasiveness through regulation of MT1-MMP traffic and invadopodia function. Oncogene, 37(50), 6425-6441.

Lim, J. P., Shyamasundar, S., Gunaratne, J., Scully, O. J., Matsumoto, K., & Bay, B. H. (2017). YBX1 gene silencing inhibits migratory and invasive potential via CORO1C in breast cancer in vitro. BMC cancer, 17(1), 1-15.

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For research use only. Not intended for any clinical use.

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