Rabbit Anti-COX11 Recombinant Antibody (EG787) (CBMAB-EN942-LY)

The product is antibody recognizes COX11. The antibody EG787 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:1000.
See all COX11 antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human

Clone

EG787

Antibody Isotype

IgG

Application

WB: 1:500~1:1000 ELISA: 1:1000

Basic Information

Immunogen

The antibody was produced against synthesized peptide derived from internal of human COX11.

Specificity

Human

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

COX11, Cytochrome C Oxidase Copper Chaperone

Introduction

COX11 (COX11, Cytochrome C Oxidase Copper Chaperone) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Gene Expression. Gene Ontology (GO) annotations related to this gene include electron transfer activity and cytochrome-c oxidase activity.

Entrez Gene ID

1353

UniProt ID

Q9Y6N1

Alternative Names

COX11, Cytochrome C Oxidase Copper Chaperone; Cytochrome C Oxidase Subunit 11; COX11 (Yeast) Homolog, Cytochrome C Oxidase Assembly Protein; Cytochrome C Oxidase Assembly Protein COX11, Mitochondrial; COX11 Homolog, Cytochrome C Oxidase Assembly Protein; Cytochrome C Oxidase Assembly Homolog 11 (Yeast); Cytochrome C Oxidase Assembly Protein COX11; COX11P;

Function

Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.

Biological Process

Metal ion homeostasis Source: UniProtKB
Negative regulation of glucokinase activity Source: Ensembl

Cellular Location

Mitochondrion inner membrane

References

Radin, I., Kost, L., Gey, U., Steinebrunner, I., & Rödel, G. (2021). The mitochondrial copper chaperone COX11 has an additional role in cellular redox homeostasis. PloS one, 16(12), e0261465.

Shibata, A., Kasai, M., Hoshino, A., Tanaka, T., & Mizuguchi, M. (2021). RANBP2 mutation causing autosomal dominant acute necrotizing encephalopathy attenuates its interaction with COX11. Neuroscience Letters, 763, 136173.

Li, W., Ding, X., Zhao, R., Xiong, D., Xie, Z., Xu, J., ... & Yang, C. (2021). The role of targeted regulation of COX11 by miR-10a-3p in the development and progression of paediatric mycoplasma pneumoniae pneumonia. Journal of Thoracic Disease, 13(9), 5409.

Radin, I., Gey, U., Kost, L., Steinebrunner, I., & Rödel, G. (2018). The mitochondrial copper chaperone COX11 plays an auxiliary role in the defence against oxidative stress. BioRxiv, 438101.

Salman, A. A. (2018). Recombinant expression and initial characterisation of two Plasmodium falciparum copper binding proteins: Cox11 and Cox19 (Doctoral dissertation).

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Datasheet
SDS
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