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Mouse Anti-COX17 Recombinant Antibody (C2121) (V2LY-1206-LY847)


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Published Data
V2LY-1206-LY847-1
Mouse Anti-COX17 Recombinant Antibody (C2121) (V2LY-1206-LY847) in WB
Western blot analysis of mitochondrial proteins' distribution between OMM (outer mitochondrial membrane), IMS (intermembrane space), and IMM (inner mitochondrial membrane) in UM-SCC-1A cells treated with vehicle (left) and SoSe (right). ...View More
Oleinik, N., Albayram, O., Kassir, M. F., Atilgan, F. C., Walton, C., Karakaya, E., ... & Ogretmen, B. (2023). Alterations of lipid-mediated mitophagy result in aging-dependent sensorimotor defects. Aging Cell, 22(10), e13954.
Distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
V2LY-1206-LY847-2
Mouse Anti-COX17 Recombinant Antibody (C2121) (V2LY-1206-LY847) in WB
RT-PCR and Western blot analysis and relative densitometry of COX17, CCS and ATOX1. ...View More
Santini, S. J., Tarantino, G., Iezzi, A., Alisi, A., & Balsano, C. (2022). Copper-catalyzed dicarbonyl stress in NAFLD mice: protective effects of Oleuropein treatment on liver damage. Nutrition & Metabolism, 19(1), 9.
Distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
C2121
Antibody Isotype
IgG2b, κ
Application
WB, IP, IF, ELISA, IHC-P

Basic Information

Immunogen
Recombinant human COX17.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000
IHC-P1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.1% gelatin
Preservative
0.09% sodium azide
Concentration
0.1 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
COX17, Cytochrome C Oxidase Copper Chaperone
Entrez Gene ID
Human10063
Mouse12856
Rat89786
UniProt ID
HumanQ14061
MouseP56394
RatQ76MV3
Function
Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2).
Biological Process
Copper ion transport Source: ProtInc
Generation of precursor metabolites and energy Source: ProtInc
Mitochondrial cytochrome c oxidase assembly Source: CAFA
Positive regulation of cell population proliferation Source: CAFA
Positive regulation of cytochrome-c oxidase activity Source: CAFA
Cellular Location
Cytoplasm; Mitochondrion intermembrane space
More Infomation

Sun, H., Chen, M., Wang, Z., Zhao, G., & Liu, J. X. (2020). Transcriptional profiles and copper stress responses in zebrafish cox17 mutants. Environmental Pollution, 256, 113364.

Chaphalkar, R., Stankowska, D. L., He, S., Kodati, B., & Krishnamoorthy, R. R. (2019). Endothelin-1 Mediated Decrease in Expression of Mitochondrial Proteins ATP5H and COX17 in Retinal Ganglion Cells. Investigative Ophthalmology & Visual Science, 60(9), 24-24.

Vanišová, M., Burska, D., Křížová, J., Daňhelovská, T., Dosoudilová, Ž., Zeman, J., ... & Hansikova, H. (2019). Stable COX17 downregulation leads to alterations in mitochondrial ultrastructure, decreased copper content and impaired cytochrome c oxidase biogenesis in HEK293 cells. Folia biologica, 65(4), 181-187.

Murtha, K., Hwang, M., Peccarelli, M. C., Scott, T. D., & Kebaara, B. W. (2019). The nonsense-mediated mRNA decay (NMD) pathway differentially regulates COX17, COX19 and COX23 mRNAs. Current genetics, 65(2), 507-521.

Singh, R. P., Jeyaraju, D. V., Voisin, V., Xu, C., Barghout, S. H., Khan, D. H., ... & Schimmer, A. (2018). Targeting the Mitochondrial Metallochaperone Cox17 Reduces DNA Methylation and Promotes AML Differentiation through a Copper Dependent Mechanism. Blood, 132, 1339.

Jeyaraju, D. V., Voisin, V., Xu, C., Barghout, S. H., Khan, D. H., Hurren, R., ... & Schimmer, A. D. (2017). Inhibiting the Mitochondrial Sulfhydryl Oxidase Alr Reduces Cox17 and Alters Mitochondrial Cristae Structure Leading to the Differentiation of AML and Stem Cells.

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For research use only. Not intended for any clinical use.

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