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Mouse Anti-COX17 Recombinant Antibody (CBYY-C3043) (V2LY-1206-LY849)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-C3043
Antibody Isotype
IgG2b, κ
Application
ELISA, WB, IHC

Basic Information

Immunogen
COX17 (aa1-63) partial recombinant protein.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
IHC3 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
COX17, Cytochrome C Oxidase Copper Chaperone
Entrez Gene ID
10063
UniProt ID
Q14061
Function
Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2).
Biological Process
Copper ion transport Source: ProtInc
Generation of precursor metabolites and energy Source: ProtInc
Mitochondrial cytochrome c oxidase assembly Source: CAFA
Positive regulation of cell population proliferation Source: CAFA
Positive regulation of cytochrome-c oxidase activity Source: CAFA
Cellular Location
Cytoplasm; Mitochondrion intermembrane space
More Infomation

Sun, H., Chen, M., Wang, Z., Zhao, G., & Liu, J. X. (2020). Transcriptional profiles and copper stress responses in zebrafish cox17 mutants. Environmental Pollution, 256, 113364.

Chaphalkar, R., Stankowska, D. L., He, S., Kodati, B., & Krishnamoorthy, R. R. (2019). Endothelin-1 Mediated Decrease in Expression of Mitochondrial Proteins ATP5H and COX17 in Retinal Ganglion Cells. Investigative Ophthalmology & Visual Science, 60(9), 24-24.

Vanišová, M., Burska, D., Křížová, J., Daňhelovská, T., Dosoudilová, Ž., Zeman, J., ... & Hansikova, H. (2019). Stable COX17 downregulation leads to alterations in mitochondrial ultrastructure, decreased copper content and impaired cytochrome c oxidase biogenesis in HEK293 cells. Folia biologica, 65(4), 181-187.

Murtha, K., Hwang, M., Peccarelli, M. C., Scott, T. D., & Kebaara, B. W. (2019). The nonsense-mediated mRNA decay (NMD) pathway differentially regulates COX17, COX19 and COX23 mRNAs. Current genetics, 65(2), 507-521.

Singh, R. P., Jeyaraju, D. V., Voisin, V., Xu, C., Barghout, S. H., Khan, D. H., ... & Schimmer, A. (2018). Targeting the Mitochondrial Metallochaperone Cox17 Reduces DNA Methylation and Promotes AML Differentiation through a Copper Dependent Mechanism. Blood, 132, 1339.

Jeyaraju, D. V., Voisin, V., Xu, C., Barghout, S. H., Khan, D. H., Hurren, R., ... & Schimmer, A. D. (2017). Inhibiting the Mitochondrial Sulfhydryl Oxidase Alr Reduces Cox17 and Alters Mitochondrial Cristae Structure Leading to the Differentiation of AML and Stem Cells.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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