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Rabbit Anti-COX17 Recombinant Antibody (EG789) (CBMAB-EN944-LY)

The product is antibody recognizes COX17. The antibody EG789 immunoassay techniques such as: WB: 1:500~1:1000 IHC: 1:50~1:100 ELISA: 1:40000.
See all COX17 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EG789
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 IHC: 1:50~1:100 ELISA: 1:40000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from N-terminal of human COX17.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
COX17, Cytochrome C Oxidase Copper Chaperone
Introduction
COX17 (COX17, Cytochrome C Oxidase Copper Chaperone) is a Protein Coding gene. Diseases associated with COX17 include Mitochondrial Metabolism Disease. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and AMPK Enzyme Complex Pathway. Gene Ontology (GO) annotations related to this gene include copper ion binding and copper chaperone activity.
Entrez Gene ID
Human10063
Mouse12856
Rat89786
UniProt ID
HumanQ14061
MouseP56394
RatQ76MV3
Alternative Names
COX17, Cytochrome C Oxidase Copper Chaperone; COX17 (Yeast) Homolog, Cytochrome C Oxidase Assembly Protein; COX17 Cytochrome C Oxidase Assembly Homolog (S. Cerevisiae);
Function
Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2).
Biological Process
Copper ion transport Source: ProtInc
Generation of precursor metabolites and energy Source: ProtInc
Mitochondrial cytochrome c oxidase assembly Source: CAFA
Positive regulation of cell population proliferation Source: CAFA
Positive regulation of cytochrome-c oxidase activity Source: CAFA
Cellular Location
Cytoplasm; Mitochondrion intermembrane space

Sun, H., Chen, M., Wang, Z., Zhao, G., & Liu, J. X. (2020). Transcriptional profiles and copper stress responses in zebrafish cox17 mutants. Environmental Pollution, 256, 113364.

Chaphalkar, R., Stankowska, D. L., He, S., Kodati, B., & Krishnamoorthy, R. R. (2019). Endothelin-1 Mediated Decrease in Expression of Mitochondrial Proteins ATP5H and COX17 in Retinal Ganglion Cells. Investigative Ophthalmology & Visual Science, 60(9), 24-24.

Vanišová, M., Burska, D., Křížová, J., Daňhelovská, T., Dosoudilová, Ž., Zeman, J., ... & Hansikova, H. (2019). Stable COX17 downregulation leads to alterations in mitochondrial ultrastructure, decreased copper content and impaired cytochrome c oxidase biogenesis in HEK293 cells. Folia biologica, 65(4), 181-187.

Murtha, K., Hwang, M., Peccarelli, M. C., Scott, T. D., & Kebaara, B. W. (2019). The nonsense-mediated mRNA decay (NMD) pathway differentially regulates COX17, COX19 and COX23 mRNAs. Current genetics, 65(2), 507-521.

Singh, R. P., Jeyaraju, D. V., Voisin, V., Xu, C., Barghout, S. H., Khan, D. H., ... & Schimmer, A. (2018). Targeting the Mitochondrial Metallochaperone Cox17 Reduces DNA Methylation and Promotes AML Differentiation through a Copper Dependent Mechanism. Blood, 132, 1339.

Jeyaraju, D. V., Voisin, V., Xu, C., Barghout, S. H., Khan, D. H., Hurren, R., ... & Schimmer, A. D. (2017). Inhibiting the Mitochondrial Sulfhydryl Oxidase Alr Reduces Cox17 and Alters Mitochondrial Cristae Structure Leading to the Differentiation of AML and Stem Cells.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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