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Mouse Anti-COX4I2 Recombinant Antibody (1F2) (CBMAB-C4035-LY)

This product is antibody recognizes COX4I2. The antibody 1F2 immunoassay techniques such as: ELISA, WB.
See all COX4I2 antibodies
Published Data
Fig. 1 Examples of immunoblots for mitochondrial proteins in vastus lateralis muscle of a subject pre- and post-endurance training in hypoxia.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
1F2
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cytochrome C Oxidase Subunit 4I2
Introduction
COX4I2 (Cytochrome C Oxidase Subunit 4I2) is a Protein Coding gene. Diseases associated with COX4I2 include Exocrine Pancreatic Insufficiency, Dyserythropoietic Anemia, And Calvarial Hyperostosis and Exocrine Pancreatic Insufficiency. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and AMPK Enzyme Complex Pathway.
Gene Ontology (GO) annotations related to this gene include cytochrome-c oxidase activity.
An important paralog of this gene is COX4I1.
Entrez Gene ID
84701
UniProt ID
Q96KJ9
Alternative Names
Cytochrome C Oxidase Subunit 4I2; Cytochrome C Oxidase Subunit IV Isoform 2 (Lung); Cytochrome C Oxidase Subunit IV Isoform 2; Cytochrome C Oxidase Subunit IV-Like 2; COX IV-2; COX4L2; Cytochrome C Oxidase Subunit 4 Isoform 2, Mitochondrial;
Function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunbit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Biological Process
Cellular respiration Source: UniProtKB
Cellular response to hypoxia Source: Ensembl
Generation of precursor metabolites and energy Source: UniProtKB
Mitochondrial electron transport, cytochrome c to oxygen Source: UniProtKB
Cellular Location
Mitochondrion inner membrane
Involvement in disease
Exocrine pancreatic insufficiency dyserythropoietic anemia and calvarial hyperostosis (EPIDACH):
Patients present with pancreatic insufficiency, intestinal malabsorption, failure to thrive, and anemia soon after birth.
Topology
Mitochondrial matrix: 29-100
Helical: 101-126
Mitochondrial intermembrane: 127-171
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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