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Rabbit Anti-COX5A Recombinant Antibody (EG794) (CBMAB-EN950-LY)

The product is antibody recognizes COX5A. The antibody EG794 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:40000.
See all COX5A antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EG794
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:40000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from Internal of human COX5A.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cytochrome C Oxidase Subunit 5A
Introduction
COX5A (Cytochrome C Oxidase Subunit 5A) is a Protein Coding gene. Diseases associated with COX5A include Mitochondrial Complex Iv Deficiency and Chronic Progressive External Ophthalmoplegia. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Gene Expression. Gene Ontology (GO) annotations related to this gene include electron transfer activity and cytochrome-c oxidase activity.
Entrez Gene ID
Human9377
Mouse12858
Rat252934
UniProt ID
HumanP20674
MouseP12787
RatP11240
Alternative Names
Cytochrome C Oxidase Subunit 5A; Cytochrome C Oxidase Polypeptide Va; Cytochrome C Oxidase Subunit Va; Cytochrome C Oxidase Polypeptide, Mitochondrial; Cytochrome C Oxidase Subunit 5A, Mitochondrial; Mitochondrial Cytochrome C Oxidase Subunit Va; COX-VA; COX; VA;
Function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Biological Process
Mitochondrial electron transport, cytochrome c to oxygen Source: GO_Central
Cellular Location
Mitochondrion inner membrane
Involvement in disease
Mitochondrial complex IV deficiency, nuclear type 20 (MC4DN20):
An autosomal recessive mitochondrial disorder with onset in early infancy. MC4DN20 is characterized by pulmonary arterial hypertension, poor feeding, failure to thrive, hypotonia, delayed development, increased serum lactate and metabolic acidosis. Death in infancy occurs due to cardiorespiratory failure. Patient tissues show variably decreased levels and activity of mitochondrial respiratory complex IV.

Zeng, J., Li, G., Xia, Y., Wang, F., Wang, Y., Xu, S., ... & Zhang, J. (2020). miR-204/COX5A axis contributes to invasion and chemotherapy resistance in estrogen receptor-positive breast cancers. Cancer Letters, 492, 185-196.

Xiyang, Y. B., Liu, R., Wang, X. Y., Li, S., Zhao, Y., Lu, B. T., ... & Zhang, J. (2020). COX5A plays a vital role in memory impairment associated with brain aging via the BDNF/ERK1/2 signaling pathway. Frontiers in aging neuroscience, 12, 215.

Jiang, Y., Bai, X., Li, T. T., Al-Hawwas, M., Jin, Y., Zou, Y., ... & Xiong, L. L. (2020). COX5A over-expression protects cortical neurons from hypoxic ischemic injury in neonatal rats associated with TPI up-regulation. BMC neuroscience, 21(1), 1-15.

Zhang, P., Chen, Z., Lu, D., Wu, Y., Fan, M., Qian, J., & Ge, J. (2020). Overexpression of COX5A protects H9c2 cells against doxorubicin-induced cardiotoxicity. Biochemical and Biophysical Research Communications, 524(1), 43-49.

Huang, Y., Li, S. N., Zhou, X. Y., Zhang, L. X., Chen, G. X., Wang, T. H., ... & Zhang, X. (2019). The dual role of AQP4 in cytotoxic and vasogenic edema following spinal cord contusion and its possible association with energy metabolism via COX5A. Frontiers in Neuroscience, 584.

Baertling, F., Al‐Murshedi, F., Sánchez‐Caballero, L., Al‐Senaidi, K., Joshi, N. P., Venselaar, H., ... & Rodenburg, R. J. (2017). Mutation in mitochondrial complex IV subunit COX5A causes pulmonary arterial hypertension, lactic acidemia, and failure to thrive. Human mutation, 38(6), 692-703.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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