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Mouse Anti-CPA4 (AA 260-361) Recombinant Antibody (CBFYC-2146) (CBMAB-C2214-FY)

This product is mouse antibody that recognizes CPA4. The antibody CBFYC-2146 can be used for immunoassay techniques such as: ELISA, IF, WB.
See all CPA4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-2146
Antibody Isotype
IgG1, k
Application
ELISA, IF, WB

Basic Information

Immunogen
CPA4 (NP_057436, 260 a.a.-361 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: NASFAGKGAS DNPCSEVYHG PHANSEVEVK SVVDFIQKHG NFKGFIDLHS YSQLLMYPYG YSVKKAPDAE ELDKVARLAA KALASVSGTE YQVGPTCTTV YP
Specificity
Human
Antibody Isotype
IgG1, k
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 260-361

Target

Full Name
carboxypeptidase A4
Introduction
CPA4 (Carboxypeptidase A4) is a Protein Coding gene. Diseases associated with CPA4 include Silver-Russell Syndrome. Gene Ontology (GO) annotations related to this gene include metallocarboxypeptidase activity and carboxypeptidase activity. An important paralog of this gene is CPA2.
Entrez Gene ID
51200
UniProt ID
Q9UI42
Alternative Names
Carboxypeptidase A4; Carboxypeptidase A3; CPA3; EC 3.4.17.1; EC 3.4.17.-; EC 3.4.1
Function
Metalloprotease that could be involved in the histone hyperacetylation pathway (PubMed:10383164).

Releases a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val (PubMed:20385563).
Biological Process
Histone acetylation Source: UniProtKB
Proteolysis Source: GO_Central
Cellular Location
Secreted

Wang, Y., Xie, Y., Niu, Y., Song, P., Liu, Y., Burnett, J., ... & Sun, L. (2021). Carboxypeptidase A4 negatively correlates with p53 expression and regulates the stemness of breast cancer cells. International Journal of Medical Sciences, 18(8), 1753.

Wei, C., Zhou, Y., Xiong, Q., Xiong, M., Hou, Y., Yang, X., & Chen, Z. (2021). Comprehensive Analysis of CPA4 as a Poor Prognostic Biomarker Correlated with Immune Cells Infiltration in Bladder Cancer. Biology, 10(11), 1143.

Gao, W., Guo, N., Zhao, S., Chen, Z., Zhang, W., Yan, F., ... & Chi, K. (2020). Carboxypeptidase A4 promotes cardiomyocyte hypertrophy through activating PI3K-AKT-mTOR signaling. Bioscience reports, 40(5).

Moon, Y., Moon, R., Roh, H., Chang, S., Lee, S., & Park, H. (2020). HIF-1α-dependent induction of carboxypeptidase A4 and carboxypeptidase E in hypoxic human adipose-derived stem cells. Molecules and Cells, 43(11), 945.

Shao, Q., Zhang, Z., Cao, R., Zang, H., Pei, W., & Sun, T. (2020). CPA4 promotes EMT in pancreatic cancer via stimulating PI3K-AKT-mTOR signaling. OncoTargets and therapy, 13, 8567.

Handa, T., Katayama, A., Yokobori, T., Yamane, A., Fujii, T., Obayashi, S., ... & Oyama, T. (2019). Carboxypeptidase A4 accumulation is associated with an aggressive phenotype and poor prognosis in triple-negative breast cancer. International journal of oncology, 54(3), 833-844.

Bademler, S., Ucuncu, M. Z., Tilgen Yasasever, C., Serilmez, M., Ertin, H., & Karanlık, H. (2019). Diagnostic and prognostic significance of carboxypeptidase A4 (CPA4) in breast cancer. Biomolecules, 9(3), 103.

Zhang, H., Hao, C., Wang, H., Shang, H., & Li, Z. (2019). Carboxypeptidase A4 promotes proliferation and stem cell characteristics of hepatocellular carcinoma. International Journal of Experimental Pathology, 100(2), 133-138.

Pan, H., Pan, J., Ji, L., Song, S., Lv, H., Yang, Z., & Guo, Y. (2019). Carboxypeptidase A4 promotes cell growth via activating STAT3 and ERK signaling pathways and predicts a poor prognosis in colorectal cancer. International journal of biological macromolecules, 138, 125-134.

Fu, Y., Su, L., Cai, M., Yao, B., Xiao, S., He, Q., ... & Huang, X. (2019). Downregulation of CPA4 inhibits non small–cell lung cancer growth by suppressing the AKT/c‐MYC pathway. Molecular carcinogenesis, 58(11), 2026-2039.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

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