Sign in or Register   Sign in or Register
  |  

Rabbit Anti-CPLX1 Recombinant Antibody (D5Q5H) (CBMAB-C2751-CN)

This product is a Rabbit antibody that recognizes CPLX1. The antibody D5Q5H can be used for immunoassay techniques such as: WB, IP, IF.
See all CPLX1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
D5Q5H
Application
WB, IP, IF

Basic Information

Specificity
Human, Mouse, Rat
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
Complexin 1
Introduction
CPLX1 (Complexin 1) is a Protein Coding gene. Diseases associated with CPLX1 include Myoclonic Epilepsy, Familial Infantile and Chromosome 4P Deletion. Among its related pathways are Transmission across Chemical Synapses and Neurotransmitter Release Cycle. Gene Ontology (GO) annotations related to this gene include syntaxin binding and syntaxin-1 binding. An important paralog of this gene is CPLX2.
Entrez Gene ID
Human10815
Mouse12889
Rat64832
UniProt ID
HumanO14810
MouseP63040
RatP63041
Alternative Names
Complexin 1; Complexin I; CPX I; Complexin-1; Synaphin 2; Synaphin-2; CPX-I; CPX1;
Function
Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles (PubMed:21785414).

Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse (PubMed:21785414).

Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior.
Biological Process
Chemical synaptic transmission Source: ProtInc
Exocytic insertion of neurotransmitter receptor to postsynaptic membrane Source: Ensembl
Exocytosis Source: ProtInc
Insulin secretion Source: Ensembl
Neurotransmitter secretion Source: Reactome
Neurotransmitter transport Source: Reactome
Regulation of exocytosis Source: ParkinsonsUK-UCL
Regulation of neurotransmitter secretion Source: GO_Central
Regulation of synaptic vesicle fusion to presynaptic active zone membrane Source: Ensembl
Synaptic vesicle exocytosis Source: GO_Central
Cellular Location
Cytosol; Perikaryon; Presynapse. Enriched at synaptic-releasing sites in mature neurons.
Involvement in disease
Developmental and epileptic encephalopathy 63 (DEE63):
A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE63 is an autosomal recessive disease with onset in infancy.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-CPLX1 Recombinant Antibody (D5Q5H)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare