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Mouse Anti-CPNE7 Recombinant Antibody (CPNE7-01) (CBMAB-1423-CN)

This product is a mouse antibody that recognizes CPNE7 of human. The antibody CPNE7-01 can be used for immunoassay techniques such as: WB.
See all CPNE7 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CPNE7-01
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Recombinant fragment corresponding to Human CPNE7 (C terminal).
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
15mM Sodium Azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Copine 7
Introduction
This gene encodes a member of the copine family, which is composed of calcium-dependent membrane-binding proteins. The encoded protein may be involved in membrane trafficking. Calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.
Entrez Gene ID
27132
UniProt ID
Q9UBL6
Alternative Names
copine-7; copine VII
Function
Calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.
Biological Process
Cellular response to calcium ion Source: UniProtKB
Glycerophospholipid biosynthetic process Source: Reactome
Lipid metabolic process Source: ProtInc
Cellular Location
Cytoplasm; Cell membrane; Nucleus. Translocates to the cell membrane in a calcium-dependent manner (PubMed:21087455).

Liu, C. Y., Tsai, C. J., Yasugaki, S., Nagata, N., Morita, M., Isotani, A., ... & Hayashi, Y. (2021). Copine-7 is required for REM sleep regulation following cage change or water immersion and restraint stress in mice. Neuroscience Research, 165, 14-25.

Ji, X., Sun, T., Xie, S., Qian, H., Liu, H., & Feng, Q. (2021). Upregulation of CPNE7 in mesenchymal stromal cells promotes oral squamous cell carcinoma metastasis through the NF-κB pathway. Cell death discovery, 7(1), 1-11.

Park, Y. H., Son, C., Seo, Y. M., Lee, Y. S., Har, A., & Park, J. C. (2021). CPNE7-Induced Autophagy Restores the Physiological Function of Mature Odontoblasts. Frontiers in Cell and Developmental Biology, 9.

Park, S. H., Lee, Y. S., Lee, D. S., Park, J. C., Kim, R., & Shon, W. J. (2019). CPNE7 induces biological dentin sealing in a dentin hypersensitivity model. Journal of Dental Research, 98(11), 1239-1244.

Park, Y. H., Lee, Y. S., Park, J. S., Kim, S. H., Bae, H. S., & Park, J. C. (2019). Expression of CPNE7 during mouse dentinogenesis. Journal of molecular histology, 50(3), 179-188.

Lee, D., Park, K. S., Yoon, G. J., Lee, H. J., Lee, J. Y., Park, Y. S., ... & Park, Y. J. (2019). Identification of cell‐penetrating osteogenic peptide from copine‐7 protein and its delivery system for enhanced bone formation. Journal of Biomedical Materials Research Part A, 107(11), 2392-2402.

Park, S. J., Lee, H. K., Seo, Y. M., Son, C., Bae, H. S., & Park, J. C. (2018). Dentin sialophosphoprotein expression in enamel is regulated by Copine-7, a preameloblast-derived factor. Archives of Oral Biology, 86, 131-137.

Jeong, D., Ban, S., Kim, H., Oh, S., Ji, S., Kim, H. J., ... & Baek, M. J. (2017). Identification of novel oncogene, copine-7 (CPNE7), in colorectal cancer.

Seo, Y. M., Park, S. J., Lee, H. K., & Park, J. C. (2017). Copine-7 binds to the cell surface receptor, nucleolin, and regulates ciliogenesis and Dspp expression during odontoblast differentiation. Scientific reports, 7(1), 1-13.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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