Mouse Anti-CPO Recombinant Antibody (1A1) (CBMAB-C3497-LY)

This product is antibody recognizes CPO. The antibody 1A1 immunoassay techniques such as: WB.
See all CPO antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

1A1

Antibody Isotype

IgG1

Application

Basic Information

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

0.68 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Carboxypeptidase O

Introduction

CPO (Carboxypeptidase O) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include metallocarboxypeptidase activity. An important paralog of this gene is CPB1.

Entrez Gene ID

130749

UniProt ID

Q8IVL8

Alternative Names

Carboxypeptidase O; Metallocarboxypeptidase O; Metallocarboxypeptidase C; EC 3.4.17.-; EC 3.4.17;

Function

Carboxypeptidase which preferentially cleaves C-terminal acidic residues from peptides and proteins. Can also cleave C-terminal hydrophobic amino acids, with a preference for small residues over large residues.

Biological Process

Proteolysis Source: GO_Central

Cellular Location

Apical cell membrane

PTM

N-glycosylated.

References

Bauza Nowotny, E. (2020). Exploring the biological function of carboxypeptidase O: analysis of expression and association with chylomicrons and lipid droplets.

Bauza Nowotny, E., & Lyons, P. J. (2019). P-22 Exploring the Role of Carboxypeptidase O in Chylomicron and Lipid Droplet Formation.

Burke, L. C., Ezeribe, H. O., Kwon, A. Y., Dockery, D., & Lyons, P. J. (2018). Carboxypeptidase O is a lipid droplet-associated enzyme able to cleave both acidic and polar C-terminal amino acids. Plos one, 13(11), e0206824.

Garcia-Guerrero, M. C., Garcia-Pardo, J., Berenguer, E., Fernandez-Alvarez, R., Barfi, G. B., Lyons, P. J., ... & Reverter, D. (2018). Crystal structure and mechanism of human carboxypeptidase O: Insights into its specific activity for acidic residues. Proceedings of the National Academy of Sciences, 115(17), E3932-E3939.

LaTour, D. (2018). Critical Amino Acids for the Folding of Carboxypeptidase O.

Lyons, P. J., Burke, L. C., Ezeribe, H. O., Kwon, A. Y., & Dockery, D. (2017). P-23 Carboxypeptidase O Is Able to Cleave both Acidic and Polar Amino Acids from Substrate Proteins within the Early Secretory Pathway.

Burke, L. C. (2017). P-26 Activity of Carboxypeptidase O in the Secretory Pathway of MDCK Cells.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-CPO Recombinant Antibody (CBXC-1897)

Mouse Anti-CPO Recombinant Antibody (1C1)

Mouse Anti-CPO Recombinant Antibody (CBFYC-2163)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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