Mouse Anti-CPT1B Recombinant Antibody (CBXC-1768) (CBMAB-C5569-CQ)

This product is a mouse antibody that recognizes CPT1B. The antibody CBXC-1768 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all CPT1B antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBXC-1768

Antibody Isotype

IgG

Application

WB, IP, IF, ELISA

Basic Information

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Carnitine Palmitoyltransferase 1B

Introduction

CPT1B (Carnitine Palmitoyltransferase 1B) is a Protein Coding gene. Diseases associated with CPT1B include Carnitine Palmitoyltransferase I Deficiency and Visceral Steatosis. Among its related pathways are Metabolism and AMP-activated Protein Kinase (AMPK) Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups and carnitine O-palmitoyltransferase activity. An important paralog of this gene is CPT1A.

Entrez Gene ID

1375

UniProt ID

Q92523

Alternative Names

Carnitine Palmitoyltransferase 1B; Carnitine Palmitoyltransferase I-Like Protein; Carnitine Palmitoyltransferase 1B (Muscle); Carnitine O-Palmitoyltransferase 1B; EC 2.3.1.21; CPT1-M; CPTI-M; Carnitine O-Palmitoyltransferase I, Mitochondrial Muscle Isoform; Carnitine O-Palmitoyltransferase 1, Muscle Isoform; Carnitine O-Palmitoyltransferase I, Muscle Isoform;

Biological Process

Carnitine metabolic process Source: GO_Central
Carnitine shuttle Source: Reactome
Fatty acid beta-oxidation Source: ProtInc
Fatty acid metabolic process Source: GO_Central
Long-chain fatty acid transport Source: GO_Central
Response to blue light Source: UniProtKB

Cellular Location

Mitochondrion outer membrane

Topology

Cytoplasmic: 1-47
Helical: 48-73
Mitochondrial intermembrane: 74-102
Helical: 103-122
Cytoplasmic: 123-772

References

Sun, Y., Fan, W., Xue, R., Dong, B., Liang, Z., Chen, C., ... & Liu, C. (2020). Transcribed ultraconserved regions, Uc. 323, ameliorates cardiac hypertrophy by regulating the transcription of CPT1b (carnitine palmitoyl transferase 1b). Hypertension, 75(1), 79-90.

Abudurexiti, M., Zhu, W., Wang, Y., Wang, J., Xu, W., Huang, Y., ... & Ye, D. (2020). Targeting CPT1B as a potential therapeutic strategy in castration‐resistant and enzalutamide‐resistant prostate cancer. The Prostate, 80(12), 950-961.

Dang, Y., Xu, J., Zhu, M., Zhou, W., Zhang, L., & Ji, G. (2020). Gan-Jiang-Ling-Zhu decoction alleviates hepatic steatosis in rats by the miR-138-5p/CPT1B axis. Biomedicine & Pharmacotherapy, 127, 110127.

Wang, C. C., Si, L. F., Li, W. Y., & Zheng, J. L. (2019). A functional gene encoding carnitine palmitoyltransferase 1 and its transcriptional and kinetic regulation during fasting in large yellow croaker. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 231, 26-33.

Warfel, J. D., Vandanmagsar, B., Dubuisson, O. S., Hodgeson, S. M., Elks, C. M., Ravussin, E., & Mynatt, R. L. (2017). Examination of carnitine palmitoyltransferase 1 abundance in white adipose tissue: implications in obesity research. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 312(5), R816-R820.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Rabbit Anti-CPT1B Recombinant Antibody (43)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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