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Mouse Anti-CPT1C Recombinant Antibody (333) (CBMAB-AP1659LY)


See all CPT1C antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
333
Antibody Isotype
IgG2b
Application
ELISA, IHC, WB

Basic Information

Immunogen
Fusion protein of CPT1C
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Carnitine Palmitoyltransferase 1C
Introduction
CPT1C (Carnitine Palmitoyltransferase 1C) is a Protein Coding gene. Diseases associated with CPT1C include Spastic Paraplegia 73, Autosomal Dominant. Among its related pathways are AMPK Enzyme Complex Pathway and AMP-activated Protein Kinase (AMPK) Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups and carnitine O-palmitoyltransferase activity. An important paralog of this gene is CPT1A.
Entrez Gene ID
126129
UniProt ID
Q8TCG5
Alternative Names
Carnitine Palmitoyltransferase 1C; Carnitine O-Palmitoyltransferase I, Brain Isoform; EC 2.3.1.21; CPT1-B; CPTI-B; CATL1; Carnitine O-Palmitoyltransferase 1, Brain Isoform;
Function
May play a role in lipid metabolic process.
Biological Process
Carnitine metabolic process Source: GO_Central
Fatty acid beta-oxidation Source: UniProtKB-UniPathway
Fatty acid metabolic process Source: GO_Central
Regulation of postsynaptic membrane neurotransmitter receptor levels Source: Ensembl
Cellular Location
Endoplasmic reticulum; Mitochondrion outer membrane; Synapse; Dendrite; Axon. Localized in the soma and dendritic and axonal projections.
Involvement in disease
Spastic paraplegia 73, autosomal dominant (SPG73):
A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.
Topology
Cytoplasmic: 1-52
Helical: 53-75
Mitochondrial intermembrane: 76-103
Helical: 104-126
Cytoplasmic: 127-803

Miralpeix, C., Reguera, A. C., Fosch, A., Casas, M., Lillo, J., Navarro, G., ... & Rodríguez‐Rodríguez, R. (2021). Carnitine palmitoyltransferase 1C negatively regulates the endocannabinoid hydrolase ABHD6 in mice, depending on nutritional status. British Journal of Pharmacology, 178(7), 1507-1523.

Zhang, H., Wang, Y., Guan, L., Chen, Y., Chen, P., Sun, J., ... & Bi, H. (2021). Lipidomics reveals carnitine palmitoyltransferase 1C protects cancer cells from lipotoxicity and senescence. Journal of pharmaceutical analysis, 11(3), 340-350.

Chen, P., Zhang, Q., Zhang, H., Gao, Y., Zhou, Y., Chen, Y., ... & Bi, H. (2021). Carnitine palmitoyltransferase 1C reverses cellular senescence of MRC‐5 fibroblasts via regulating lipid accumulation and mitochondrial function. Journal of Cellular Physiology, 236(2), 958-970.

Ding, Y., Zhang, H., Liu, Z., Li, Q., Guo, Y., Chen, Y., ... & Cui, H. (2021). Carnitine palmitoyltransferase 1 (CPT1) alleviates oxidative stress and apoptosis of hippocampal neuron in response to beta-Amyloid peptide fragment Aβ25-35. Bioengineered, 12(1), 5440-5449.

Wang, Y., Yu, T., Zhou, Y., Wang, S., Zhou, X., Wang, L., ... & Bi, H. (2020). Carnitine palmitoyltransferase 1C contributes to progressive cellular senescence. Aging (Albany NY), 12(8), 6733.

Chen, Y., Zhou, Y., Han, F., Zhao, Y., Tu, M., Wang, Y., ... & Bi, H. (2020). A novel miR-1291-ERRα-CPT1C axis modulates tumor cell proliferation, metabolism and tumorigenesis. Theranostics, 10(16), 7193.

Wang, Y., Chen, Y., Guan, L., Zhang, H., Huang, Y., Johnson, C. H., ... & Bi, H. (2018). Carnitine palmitoyltransferase 1C regulates cancer cell senescence through mitochondria-associated metabolic reprograming. Cell Death & Differentiation, 25(4), 735-748.

Roa-Mansergas, X., Fadó, R., Atari, M., Mir, J. F., Muley, H., Serra, D., & Casals, N. (2018). CPT1C promotes human mesenchymal stem cells survival under glucose deprivation through the modulation of autophagy. Scientific reports, 8(1), 1-13.

Chen, Y., Wang, Y., Huang, Y., Zeng, H., Hu, B., Guan, L., ... & Bi, H. (2017). PPARα regulates tumor cell proliferation and senescence via a novel target gene carnitine palmitoyltransferase 1C. Carcinogenesis, 38(4), 474-483.

Pozo, M., Rodríguez-Rodríguez, R., Ramírez, S., Seoane-Collazo, P., López, M., Serra, D., ... & Casals, N. (2017). Hypothalamic regulation of liver and muscle nutrient partitioning by brain-specific carnitine palmitoyltransferase 1C in male mice. Endocrinology, 158(7), 2226-2238.

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For research use only. Not intended for any clinical use.

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