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Mouse Anti-CRABP1 Recombinant Antibody (C-1) (CBMAB-1425-CN)

This product is a mouse antibody that recognizes CRABP1 of bovine. The antibody C-1 can be used for immunoassay techniques such as: ELISA, FC, IF, IHC, IHC-Fr, IHC-P, WB.
See all CRABP1 antibodies
Published Data
Fig.1 In vitro interaction assay. Flag-CaMKII captured by M2 beads from TnT synthesized products interacted with His-CRABP1 independent of Ca2+.
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Fig.2 ERK activation elicited by RA and compounds 3 and 4 for 30 min is abolished in Crabp1 KO ESC.
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Fig.3 Representative results of immunohistochemical staining of CRABP1 protein.
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Fig.4 Examples of immunohistochemical staining of CRABP1 (×400).
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Fig.5 Examples of immunohistochemical staining of CRABP1.
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Summary

Host Animal
Mouse
Specificity
Cattle, Human, Mouse, Chicken, Rat, Cat, Rabbit
Clone
C-1
Antibody Isotype
IgG2b
Application
ELISA, FC, IF, IHC, IHC-Fr, IHC-P, WB

Basic Information

Immunogen
Oxidized CRABP1 from bovine retina
Specificity
Cattle, Human, Mouse, Chicken, Rat, Cat, Rabbit
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Ascites
Preservative
0.05% Sodium azide
Concentration
5.40 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cellular Retinoic Acid Binding Protein 1
Introduction
This gene encodes a specific binding protein for a vitamin A family member and is thought to play an important role in retinoic acid-mediated differentiation and proliferation processes. Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.
Entrez Gene ID
Human1381
Mouse12903
Rat25061
Cattle282201
Chicken374211
Cat101090941
Rabbit100338607
UniProt ID
HumanP29762
MouseP62965
RatP62966
CattleP62964
ChickenP40220
CatM3WDF2
RabbitG1SDA2
Alternative Names
cellular retinoic acid-binding protein 1; CRABP-I; cellular retinoic acid-binding protein I
Function
Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.
Biological Process
Multicellular organism development Source: ProtInc
Retinoic acid catabolic process Source: InterPro
Signal transduction Source: ProtInc
Cellular Location
Cytoplasm

Lin, Y. W., Nhieu, J., Wei, C. W., Lin, Y. L., Kagechika, H., & Wei, L. N. (2021). Regulation of exosome secretion by cellular retinoic acid binding protein 1 contributes to systemic anti-inflammation. Cell Communication and Signaling, 19(1), 1-11.

Enikeev, A. D., Komelkov, A. V., Axelrod, M. E., Galetsky, S. A., Kuzmichev, S. A., & Tchevkina, E. M. (2021). CRABP1 and CRABP2 protein levels correlate with each other but do not correlate with sensitivity of breast cancer cells to retinoic acid. Biochemistry (Moscow), 86(2), 217-229.

Lin, Y. L., Lin, Y. W., Nhieu, J., Zhang, X., & Wei, L. N. (2020). Sonic hedgehog-gli1 signaling and cellular retinoic acid binding protein 1 gene regulation in motor neuron differentiation and diseases. International journal of molecular sciences, 21(11), 4125.

Lin, Y. W., Park, S. W., Lin, Y. L., Burton, F. H., & Wei, L. N. (2020). Cellular retinoic acid binding protein 1 protects mice from high-fat diet-induced obesity by decreasing adipocyte hypertrophy. International journal of obesity, 44(2), 466-474.

Park, S. W., Nhieu, J., Persaud, S. D., Miller, M. C., Xia, Y., Lin, Y. W., ... & Wei, L. N. (2019). A new regulatory mechanism for Raf kinase activation, retinoic acid-bound Crabp1. Scientific reports, 9(1), 1-12.

Nagpal, I., & Wei, L. N. (2019). All-trans retinoic acid as a versatile cytosolic signal modulator mediated by CRABP1. International journal of molecular sciences, 20(15), 3610.

Park, S. W., Nhieu, J., Lin, Y. W., & Wei, L. N. (2019). All-trans retinoic acid attenuates isoproterenol-induced cardiac dysfunction through Crabp1 to dampen CaMKII activation. European journal of pharmacology, 858, 172485.

Lin, Y. L., Persaud, S. D., Nhieu, J., & Wei, L. N. (2017). Cellular retinoic acid–binding protein 1 modulates stem cell proliferation to affect learning and memory in male mice. Endocrinology, 158(9), 3004-3014.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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