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Rabbit Anti-CRADD Recombinant Antibody (CBCNC-014) (CBMAB-R0480-CN)

This product is a Rabbit antibody that recognizes CRADD. The antibody CBCNC-014 can be used for immunoassay techniques such as: FC, IF, IHC-P, IP, WB.
See all CRADD antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBCNC-014
Antibody Isotype
IgG
Application
FC, IF, IHC-P, IP, WB

Basic Information

Immunogen
A synthetic peptide corresponding to residues on the C-terminus of human RAIDD
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
50mM Tris-Glycine, pH 7.4, 0.15M NaCl, 0.05% BSA, 40% Glycerol
Preservative
0.01% Sodium azide

Target

Full Name
CASP2 and RIPK1 domain containing adaptor with death domain
Introduction
CRADD (CASP2 And RIPK1 Domain Containing Adaptor With Death Domain) is a Protein Coding gene. Diseases associated with CRADD include Mental Retardation, Autosomal Recessive 34, With Variant Lissencephaly and Autosomal Recessive Non-Syndromic Intellectual Disability. Among its related pathways are Apoptosis Modulation and Signaling and Apoptosis and survival Caspase cascade. Gene Ontology (GO) annotations related to this gene include protease binding and death domain binding.
Entrez Gene ID
8738
UniProt ID
P78560
Alternative Names
CASP2 And RIPK1 Domain Containing Adaptor With Death Domain; RIP-Associated ICH1/CED3-Homologous Protein With Death Domain; RAIDD; RIP-Associated Protein With A Death Domain; Caspase And RIP Adaptor With Death Domain; Caspase And RIP Adapter With Death Domain;
Function
Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis (PubMed:9044836, PubMed:15073321, PubMed:16652156, PubMed:17159900, PubMed:17289572).

Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway (PubMed:8985253).
Biological Process
Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: GO_Central
Apoptotic signaling pathway Source: UniProtKB
Cellular response to mechanical stimulus Source: UniProtKB
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: UniProtKB
Extrinsic apoptotic signaling pathway via death domain receptors Source: BHF-UCL
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of apoptotic signaling pathway Source: GO_Central
Regulation of apoptotic process Source: Reactome
Cellular Location
Nucleus; Cytoplasm
Involvement in disease
Mental retardation, autosomal recessive 34, with variant lissencephaly (MRT34):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT34 is a non-syndromic form. Affected individuals have mildly delayed development and significantly impaired cognitive function, precluding independent living and self-care. Speech is rudimentary, but articulate; autism is not present.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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