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Mouse Anti-CRISP3 Recombinant Antibody (295203) (CBMAB-C4555-LY)

This product is antibody recognizes CRISP3. The antibody 295203 immunoassay techniques such as: IHC-P.
See all CRISP3 antibodies
Published Data
Fig.1 Western blot with human CRISP3 antibody showing CRISP3 induction.
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Fig.2 CRISP3 expression is strong in the cytoplasm of basal cells and peripapillary cells and in mature superficial squamous cells of control samples.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
295203
Antibody Isotype
IgG1
Application
IHC-P

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant human CRISP-3 Asn21-Tyr245 (Ser106Pro and Ala134Ser)
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
5% trehalose
Concentration
0.5 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cysteine Rich Secretory Protein 3
Introduction
CRISP3 (Cysteine Rich Secretory Protein 3) is a Protein Coding gene. Diseases associated with CRISP3 include Prostate Cancer. Among its related pathways are Innate Immune System.

An important paralog of this gene is CRISP2.
Entrez Gene ID
10321
UniProt ID
P54108
Alternative Names
Cysteine Rich Secretory Protein 3; CRISP-3; SGP28; Specific Granule Protein Of 28 KDa; Cysteine-Rich Secretory Protein 3; Specific Granule Protein (28 KDa); DJ442L6.3; Aeg2; CRS3;
Biological Process
Defense response Source: UniProtKB
Innate immune response Source: UniProtKB
Neutrophil degranulation Source: Reactome
Cellular Location
Secreted. In neutrophils, localized in specific granules.

Shen, Q., Xu, Z., Sun, G., Wang, H., & Zhang, L. (2021). LINC01342 silencing upregulates microRNA-508-5p to inhibit progression of lung cancer by reducing cysteine-rich secretory protein 3. Cell death discovery, 7(1), 1-9.

Belardin, L., Camargo, M., Intasqui, P., Antoniassi, M., Fraietta, R., & Bertolla, R. (2019). Cysteine‐rich secretory protein 3: inflammation role in adult varicocoele. Andrology, 7(1), 53-61.

Restrepo, G., Rojano, B., & Usuga, A. (2019). Relationship of cysteine‐rich secretory protein‐3 gene and protein with semen quality in stallions. Reproduction in Domestic Animals, 54(1), 39-45.

Usuga, A., Rojano, B. A., & Restrepo, G. (2018). Association of the cysteine-rich secretory protein-3 (CRISP-3) and some of its polymorphisms with the quality of cryopreserved stallion semen. Reproduction, Fertility and Development, 30(3), 563-569.

Volpert, M., Hu, J., Rebello, R., O’Bryan, M., & Furic, L. (2018). PO-230 Cysteine-rich secretory protein 3 regulates progression from in situ to invasive prostate cancer. ESMO Open, 3, A317.

Fedorka, C. E., Scoggin, K. E., Squires, E. L., Ball, B. A., & Troedsson, M. H. T. (2017). Expression and localization of cysteine-rich secretory protein-3 (CRISP-3) in the prepubertal and postpubertal male horse. Theriogenology, 87, 187-192.

Fedorka, C. E., Woodward, E. M., Scoggin, K. E., Esteller-Vico, A., Squires, E. L., Ball, B. A., & Troedsson, M. H. (2017). The effect of cysteine-rich secretory protein-3 and lactoferrin on endometrial cytokine mRNA expression after breeding in the horse. Journal of Equine Veterinary Science, 48, 136-142.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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