Rabbit Anti-CRKL Recombinant Antibody (EP270Y) (CBMAB-1442-CN)

Rabbit

Human, Mouse

EP270Y

IgG

WB, IP

A synthetic phospho peptide corresponding to residues surrounding Tyr207 of human CrkL

Human, Mouse

IgG

Monoclonal

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Liquid

49% PBS, 0.05% BSA, 50% Glycerol

0.01% Sodium azide

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

CRK Like Proto-Oncogene, Adaptor Protein

This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic. The encoded protein may mediate the transduction of intracellular signals.

crk-like protein; v-crk avian sarcoma virus CT10 oncogene homolog-like

May mediate the transduction of intracellular signals.

Acetylcholine receptor signaling pathway Source: Ensembl
Activation of GTPase activity Source: Ensembl
Activation of MAPK activity Source: Ensembl
Activation of MAPKK activity Source: Reactome
Anterior/posterior pattern specification Source: Ensembl
B cell apoptotic process Source: Ensembl
Blood vessel development Source: Ensembl
Cell chemotaxis Source: Ensembl
Cellular response to drug Source: Ensembl
Cellular response to interleukin-7 Source: Ensembl
Cellular response to transforming growth factor beta stimulus Source: ARUK-UCL
Cerebellar neuron development Source: Ensembl
Cerebral cortex development Source: Ensembl
Cranial skeletal system development Source: Ensembl
Cytokine-mediated signaling pathway Source: Reactome
Dendrite development Source: Ensembl
Endothelin receptor signaling pathway Source: Ensembl
Establishment of cell polarity Source: Ensembl
Fibroblast growth factor receptor signaling pathway Source: Ensembl
Helper T cell diapedesis Source: Ensembl
Hippocampus development Source: Ensembl
Intracellular signal transduction Source: ProtInc
JNK cascade Source: ProtInc
Lipid metabolic process Source: Ensembl
Male gonad development Source: Ensembl
Negative regulation of gene expression Source: ARUK-UCL
Negative regulation of protein phosphorylation Source: ARUK-UCL
Neuron migration Source: Ensembl
Outflow tract morphogenesis Source: Ensembl
Parathyroid gland development Source: Ensembl
Pharynx development Source: Ensembl
Positive regulation of cell population proliferation Source: CACAO
Positive regulation of ERK1 and ERK2 cascade Source: ARUK-UCL
Positive regulation of glial cell migration Source: ARUK-UCL
Positive regulation of protein phosphorylation Source: ARUK-UCL
Positive regulation of Ras protein signal transduction Source: Reactome
Positive regulation of substrate adhesion-dependent cell spreading Source: UniProtKB
Ras protein signal transduction Source: ProtInc
Reelin-mediated signaling pathway Source: Ensembl
Regulation of cell adhesion mediated by integrin Source: Ensembl
Regulation of cell growth Source: Ensembl
Regulation of dendrite development Source: Ensembl
Regulation of skeletal muscle acetylcholine-gated channel clustering Source: Ensembl
Regulation of T cell migration Source: Ensembl
Retinoic acid receptor signaling pathway Source: Ensembl
Single fertilization Source: Ensembl
Spermatogenesis Source: Ensembl
Synapse assembly Source: Ensembl
T cell receptor signaling pathway Source: Ensembl
Thymus development Source: Ensembl
Urogenital system development Source: Ensembl

Cytosol; Nucleoplasm; Extrinsic component of postsynaptic membrane; Neuromuscular junction; Protein-containing complex