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Mouse Anti-CRTC1 Recombinant Antibody (1B5) (CBMAB-C3650-LY)

This product is antibody recognizes CRTC1. The antibody 1B5 immunoassay techniques such as: ELISA, WB, IF/IHC-F, FC.
See all CRTC1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1B5
Antibody Isotype
IgG1
Application
ELISA, WB, IF/IHC-F, FC

Basic Information

Immunogen
Purified recombinant fragment of human CRTC1 expressed in E. Coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Preservative
0.03% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CREB Regulated Transcription Coactivator 1
Introduction
CRTC1 (CREB Regulated Transcription Coactivator 1) is a Protein Coding gene. Diseases associated with CRTC1 include Mucoepidermoid Carcinoma and Clear Cell Hidradenoma. Among its related pathways are Mesodermal Commitment Pathway and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include cAMP response element binding protein binding.
An important paralog of this gene is CRTC2.
Entrez Gene ID
23373
UniProt ID
Q6UUV9
Alternative Names
CREB Regulated Transcription Coactivator 1; Mucoepidermoid Carcinoma Translocated Protein 1; TORC-1; WAMTP1; MECT1; TORC1; Transducer Of Regulated CAMP Response Element-Binding Protein (CREB) 1;
Function
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity).

In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock.

(Microbial infection) Plays a role of coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).
Biological Process
Energy homeostasis Source: Ensembl
Entrainment of circadian clock by photoperiod Source: UniProtKB
Memory Source: Ensembl
Negative regulation of membrane hyperpolarization Source: Ensembl
Positive regulation of CREB transcription factor activity Source: UniProtKB
Positive regulation of dendrite development Source: Ensembl
Positive regulation of long-term synaptic potentiation Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Postsynapse to nucleus signaling pathway Source: Ensembl
Protein homotetramerization Source: InterPro
Rhythmic process Source: UniProtKB-KW
Viral process Source: UniProtKB-KW
Cellular Location
Cytoplasm; Nucleus. Cytoplasmic when phosphorylated by SIK or AMPK and when sequestered by 14-3-3 proteins (PubMed:16817901). Translocated to the nucleus on Ser-151 dephosphorylation, instigated by a number of factors including calcium ion and cAMP levels (PubMed:15589160). Light stimulation triggers a nuclear accumulation in the suprachiasmatic nucleus (SCN) of the brain (By similarity).
Involvement in disease
A chromosomal aberration involving CRTC1 is found in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. Translocation t(11;19)(q21;p13) with MAML2. The fusion protein consists of the N-terminus of CRTC1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of CRTC1 has been detected in a small number of mucoepidermoid carcinomas.
PTM
Phosphorylation/dephosphorylation states of Ser-151 are required for regulating transduction of CREB activity. TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. This primary site of phosphorylation is mediated by SIKs (SIK1 and SIK2), is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs by LKB1 (By similarity).

Rossetti, C., Cherix, A., Guiraud, L. F., & Cardinaux, J. R. (2022). New Insights Into the Pivotal Role of CREB-Regulated Transcription Coactivator 1 in Depression and Comorbid Obesity. Frontiers in Molecular Neuroscience, 15.

Pan, Y., He, X., Li, C., Li, Y., Li, W., Zhang, H., ... & Ma, H. (2021). Neuronal activity recruits the CRTC1/CREB axis to drive transcription-dependent autophagy for maintaining late-phase LTD. Cell Reports, 36(3), 109398.

Jiang, B., Wang, H., Wang, J. L., Wang, Y. J., Zhu, Q., Wang, C. N., ... & Li, J. X. (2019). Hippocampal Salt-Inducible Kinase 2 Plays a Role in Depression via the CREB-Regulated Transcription Coactivator 1–cAMP Response Element Binding–Brain-Derived Neurotrophic Factor Pathway. Biological psychiatry, 85(8), 650-666.

Ni, S., Huang, H., He, D., Chen, H., Wang, C., Zhao, X., ... & Zhang, J. (2019). Adeno‐associated virus‐mediated over‐expression of CREB‐regulated transcription coactivator 1 in the hippocampal dentate gyrus ameliorates lipopolysaccharide‐induced depression‐like behaviour in mice. Journal of Neurochemistry, 149(1), 111-125.

Morhenn, K., Quentin, T., Wichmann, H., Steinmetz, M., Prondzynski, M., Söhren, K. D., ... & Oetjen, E. (2019). Mechanistic role of the CREB-regulated transcription coactivator 1 in cardiac hypertrophy. Journal of molecular and cellular cardiology, 127, 31-43.

Kim, M. K., Kwon, J. O., Song, M. K., Kim, B., Kim, H., Lee, Z. H., ... & Kim, H. H. (2019). Salt-inducible kinase 1 regulates bone anabolism via the CRTC1–CREB–Id1 axis. Cell death & disease, 10(11), 1-15.

Saura, C. A., & Cardinaux, J. R. (2017). Emerging roles of CREB-regulated transcription coactivators in brain physiology and pathology. Trends in neurosciences, 40(12), 720-733.

Parra-Damas, A., Chen, M., Enriquez-Barreto, L., Ortega, L., Acosta, S., Perna, J. C., ... & Saura, C. A. (2017). CRTC1 function during memory encoding is disrupted in neurodegeneration. Biological psychiatry, 81(2), 111-123.

Parra-Damas, A., Rubió-Ferrarons, L., Shen, J., & Saura, C. A. (2017). CRTC1 mediates preferential transcription at neuronal activity-regulated CRE/TATA promoters. Scientific reports, 7(1), 1-13.

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For research use only. Not intended for any clinical use.

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