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Mouse Anti-CRYBA1 Recombinant Antibody (CBCNC-376) (CBMAB-C2897-CN)

This product is a Mouse antibody that recognizes CRYBA1. The antibody CBCNC-376 can be used for immunoassay techniques such as: WB.
See all CRYBA1 antibodies

Summary

Host Animal
Mouse
Specificity
Cattle
Clone
CBCNC-376
Antibody Isotype
IgG1
Application
WB

Basic Information

Specificity
Cattle
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2, 0.1 mM PMSF, 50% glycerol

Target

Full Name
Crystallin Beta A1
Introduction
CRYBA1 (Crystallin Beta A1) is a Protein Coding gene. Diseases associated with CRYBA1 include Cataract 10, Multiple Types and Cataract 25. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and structural constituent of eye lens. An important paralog of this gene is CRYBA4.
Entrez Gene ID
282202
UniProt ID
P11843
Alternative Names
Crystallin Beta A1; Eye Lens Structural Protein; CRYB1; Beta Crystallin A3 Chain Transcript LAM; Beta Crystallin A3 Chain Transcript CN; Beta Crystallin A3 Chain Transcript PS; Beta Crystallin A3 Chain Transcript TC; Truncated Beta Crystallin A3/A1 Chain;
Function
Crystallins are the dominant structural components of the vertebrate eye lens.
Biological Process
Lens development in camera-type eye Source: GO_Central
Negative regulation of cytokine production Source: Ensembl
Negative regulation of ERK1 and ERK2 cascade Source: Ensembl
Negative regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
Negative regulation of protein kinase B signaling Source: Ensembl
Negative regulation of TOR signaling Source: Ensembl
Positive regulation of anoikis Source: Ensembl
Visual perception Source: UniProtKB
Cellular Location
Nucleus; Cytoplasm
Involvement in disease
Cataract 10, multiple types (CTRCT10):
An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. CTRCT10 includes congenital zonular with sutural opacities, among others. This is a form of zonular cataract with an erect Y-shaped anterior and an inverted Y-shaped posterior sutural opacities. Zonular or lamellar cataracts are opacities, broad or narrow, usually consisting of powdery white dots affecting only certain layers or zones between the cortex and nucleus of an otherwise clear lens. The opacity may be so dense as to render the entire central region of the lens completely opaque, or so translucent that vision is hardly if at all impeded. Zonular cataracts generally do not involve the embryonic nucleus, though sometimes they involve the fetal nucleus. Usually sharply separated from a clear cortex outside them, they may have projections from their outer edges known as riders or spokes.
PTM
Specific cleavages in the N-terminal arm occur during lens maturation and give rise to several truncated forms. Cleavages do not seem to have adverse effects on solubility.
S-methylation and glutathionylation occur in normal young lenses and do not seem to be detrimental.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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