Mouse Anti-CRYBB2 Recombinant Antibody (14i19) (CBMAB-C0345-LY)

This product is antibody recognizes CRYBB2. The antibody 14i19 immunoassay techniques such as: IHC-F, WB.
See all CRYBB2 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Mouse, Rat

Clone

14i19

Antibody Isotype

IgG

Application

IHC-F, WB

Basic Information

Immunogen

Recombinant protein corresponding to human CRYBB2

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

50% glycerol

Preservative

0.02% sodium azide

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Crystallin Beta B2

Introduction

CRYBB2 (Crystallin Beta B2) is a Protein Coding gene. Diseases associated with CRYBB2 include Cataract 3, Multiple Types and Cerulean Cataract. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and structural molecule activity. An important paralog of this gene is CRYBB3.

Entrez Gene ID

1415

UniProt ID

P43320

Alternative Names

Crystallin Beta B2; Beta-B2 Crystallin; Beta-Crystallin Bp; CRYB2A; CRYB2; Eye Lens Structural Protein; Crystallin, Beta B2;

Function

Crystallins are the dominant structural components of the vertebrate eye lens.

Biological Process

Lens development in camera-type eye Source: GO_Central
Response to stimulus Source: UniProtKB-KW
Visual perception Source: GO_Central

Involvement in disease

Cataract 3, multiple types (CTRCT3):
An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. CTRCT3 includes congenital cerulean and sutural cataract with punctate and cerulean opacities, among others. Cerulean cataract is characterized by peripheral bluish and white opacifications organized in concentric layers with occasional central lesions arranged radially. The opacities are observed in the superficial layers of the fetal nucleus as well as the adult nucleus of the lens. Involvement is usually bilateral. Visual acuity is only mildly reduced in childhood. In adulthood, the opacifications may progress, making lens extraction necessary. Histologically the lesions are described as fusiform cavities between lens fibers which contain a deeply staining granular material. Although the lesions may take on various colors, a dull blue is the most common appearance and is responsible for the designation cerulean cataract. Sutural cataract with punctate and cerulean opacities is characterized by white opacification around the anterior and posterior Y sutures, and grayish and bluish, spindle shaped, oval punctate and cerulean opacities of various sizes arranged in lamellar form. The spots are more concentrated towards the peripheral layers and do not delineate the embryonal or fetal nucleus. Phenotypic variation with respect to the size and density of the sutural opacities as well as the number and position of punctate and cerulean spots is observed among affected subjects.

References

Xu, L. J., Lv, Z. G., Liu, Y., Zhang, X. X., Cui, Y. X., Li, X. C., ... & He, J. (2021). A novel CRYBB2 mutation causes autosomal dominant cataract: A report from a Chinese family. European Journal of Ophthalmology, 31(5), NP57-NP64.

Chen, D., & Zhu, S. (2021). Whole‑exome sequencing identification of a recurrent CRYBB2 variant in a four‑generation Chinese family with congenital nuclear cataracts. Experimental and Therapeutic Medicine, 22(6), 1-13.

Giegling, I., Hartmann, A. M., Genius, J., Konte, B., Maul, S., Straube, A., ... & Rujescu, D. (2020). Polymorphisms in CRYBB2 encoding βB2-crystallin are associated with antisaccade performance and memory function. Translational Psychiatry, 10(1), 1-12.

Sun, M., Ahmad, N., Zhang, R., & Graw, J. (2018). Crybb2 associates with Tmsb4X and is crucial for dendrite morphogenesis. Biochemical and biophysical research communications, 503(1), 123-130.

Chen, P., Chen, H., Pan, X. J., Tang, S. Z., Xia, Y. J., & Zhang, H. (2018). Novel mutations in CRYBB1/CRYBB2 identified by targeted exome sequencing in Chinese families with congenital cataract. International Journal of Ophthalmology, 11(10), 1577.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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