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Mouse Anti-CRYGD Recombinant Antibody (4E12) (CBMAB-C6848-LY)

This product is antibody recognizes CRYGD. The antibody 4E12 immunoassay techniques such as: ELISA, WB.
See all CRYGD antibodies
Published Data
Fig. 1 Fluorescent micrographs of HEK293 cells expressing the R37S variant. On day-4 post-transfection, cells were fixed, permeabilized, and immunostained by using mouse anti-CRYGD mAb.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
4E12
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Crystallin Gamma D
Introduction
CRYGD (Crystallin Gamma D) is a Protein Coding gene. Diseases associated with CRYGD include Cataract 4, Multiple Types and Cataract 29. Gene Ontology (GO) annotations related to this gene include structural constituent of eye lens. An important paralog of this gene is CRYGB.
Entrez Gene ID
1421
UniProt ID
P07320
Alternative Names
Crystallin Gamma D; Gamma-D-Crystallin; CRYG4; Crystallin, Gamma D; Gamma Crystallin 4; Gamma-Crystallin D; Gamma-Crystallin 4;
Function
Crystallins are the dominant structural components of the vertebrate eye lens.
Biological Process
Cellular response to reactive oxygen species Source: UniProtKB
Lens development in camera-type eye Source: UniProtKB
Lens fiber cell differentiation Source: UniProtKB
Visual perception Source: UniProtKB
Cellular Location
Nucleus; Cytoplasm
Involvement in disease
Cataract 4, multiple types (CTRCT4):
An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. CTRCT4 includes crystalline aculeiform, congenital cerulean and non-nuclear polymorphic cataracts, among others. Crystalline aculeiform cataract is characterized by fiberglass-like or needle-like crystals projecting in different directions, through or close to the axial region of the lens. Non-nuclear polymorphic cataract is a partial opacity with variable location between the fetal nucleus of the lens and the equator. The fetal nucleus is normal. The opacities are irregular and look similar to a bunch of grapes and may be present simultaneously in different lens layers. Congenital cerulean cataract is characterized by peripheral bluish and white opacifications organized in concentric layers with occasional central lesions arranged radially. The opacities are observed in the superficial layers of the fetal nucleus as well as the adult nucleus of the lens. Involvement is usually bilateral. Visual acuity is only mildly reduced in childhood. In adulthood, the opacifications may progress, making lens extraction necessary. Histologically the lesions are described as fusiform cavities between lens fibers which contain a deeply staining granular material. Although the lesions may take on various colors, a dull blue is the most common appearance and is responsible for the designation cerulean cataract.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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