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Rabbit Anti-CSDE1 Recombinant Antibody (EPR17413) (CBMAB-1454-CN)

This product is a rabbit antibody that recognizes CSDE1 of human. The antibody EPR17413 can be used for immunoassay techniques such as: WB, IP.
See all CSDE1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EPR17413
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Synthetic peptide within Human CSDE1 aa. 50-150.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
59% PBS, 40% Glycerol, 0.05% BSA
Preservative
0.01% Sodium azide
Concentration
1.125 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CSDE1
Introduction
CSDE1 (cold shock domain containing E1, RNA-binding) is a protein that in humans is encoded by the CSDE1 gene. CSDE1 also known as Unr (upstream of N-ras), encodes an RNA-binding protein implicated in the post-transcriptional regulation of a subset of cellular mRNA.
Entrez Gene ID
Human7812
Mouse229663
Rat117180
UniProt ID
HumanO75534
MouseQ91W50
RatP18395
Alternative Names
UNR; D1S155E
Function
RNA-binding protein involved in translationally coupled mRNA turnover (PubMed:11051545, PubMed:15314026).

Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545, PubMed:15314026).

Required for efficient formation of stress granules (PubMed:29395067).

RNA-binding protein involved in translationally coupled mRNA turnover (PubMed:11051545, PubMed:15314026).

Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545, PubMed:15314026).

Required for efficient formation of stress granules (PubMed:29395067).
Biological Process
IRES-dependent viral translational initiation Source: FlyBase
Male gonad development Source: ProtInc
Nuclear-transcribed mRNA catabolic process, no-go decay Source: UniProtKB
Regulation of translational initiation Source: FlyBase
Stress granule assembly Source: UniProtKB
Cellular Location
Cytoplasm; Stress granule; P-body

El Khouri, E., Ghoumid, J., Haye, D., Giuliano, F., Drevillon, L., Briand-Suleau, A., ... & Giurgea, I. (2021). Wnt/β-catenin pathway and cell adhesion deregulation in CSDE1-related intellectual disability and autism spectrum disorders. Molecular Psychiatry, 26(7), 3572-3585.

Kottke, T., Tonne, J., Evgin, L., Driscoll, C. B., van Vloten, J., Jennings, V. A., ... & Vile, R. G. (2021). Oncolytic virotherapy induced CSDE1 neo-antigenesis restricts VSV replication but can be targeted by immunotherapy. Nature communications, 12(1), 1-15.

Liu, H., Li, X., Dun, M. D., Faulkner, S., Jiang, C. C., & Hondermarck, H. (2020). Cold shock domain containing E1 (CSDE1) protein is overexpressed and can be targeted to inhibit invasiveness in pancreatic cancer cells. Proteomics, 20(10), 1900331.

Duan, H., He, H., Hu, Q., Lin, Y., Cao, S., Lan, X., ... & Pang, D. (2020). Comparison of regulatory networks of E74‑like factor 1 and cold‑shock domain‑containing E1 in breast cancer cell lines using ChIP datasets. Experimental and therapeutic medicine, 20(6), 1-1.

Guo, A. X., Cui, J. J., Wang, L. Y., & Yin, J. Y. (2020). The role of CSDE1 in translational reprogramming and human diseases. Cell Communication and Signaling, 18(1), 1-12.

Xie, P., & Guo, Y. (2020). LINC00205 promotes malignancy in lung cancer by recruiting FUS and stabilizing CSDE1. Bioscience reports, 40(10).

Martinez-Useros, J., Garcia-Carbonero, N., Li, W., Fernandez-Aceñero, M. J., Cristobal, I., Rincon, R., ... & Garcia-Foncillas, J. (2019). UNR/CSDE1 expression is critical to maintain invasive phenotype of colorectal cancer through regulation of c-MYC and epithelial-to-mesenchymal transition. Journal of clinical medicine, 8(4), 560.

Moore, K. S., Yagci, N., van Alphen, F., Paolini, N. A., Horos, R., Held, N. M., ... & von Lindern, M. (2018). Csde1 binds transcripts involved in protein homeostasis and controls their expression in an erythroid cell line. Scientific reports, 8(1), 1-14.

Ju Lee, H., Bartsch, D., Xiao, C., Guerrero, S., Ahuja, G., Schindler, C., ... & Vilchez, D. (2017). A post-transcriptional program coordinated by CSDE1 prevents intrinsic neural differentiation of human embryonic stem cells. Nature communications, 8(1), 1-19.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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