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Mouse Anti-CSP Recombinant Antibody (CBWJC-3241) (CBMAB-C4432WJ)

This product is a Mouse antibody that recognizes CSP. This antibody CBWJC-3241 can be used for immunoassay techniques such as: ELISA, WB.
See all CSP antibodies

Summary

Host Animal
Mouse
Specificity
Plasmodium vivax
Clone
CBWJC-3241
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Immunogen
Recombinant P. vivax CSP
Specificity
Plasmodium vivax
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CSP
Introduction
Cysteine string protein may have an important role in presynaptic function.
Entrez Gene ID
UniProt ID
Alternative Names
CG6395; cysteine string protein
Function
May have an important role in presynaptic function.
Biological Process
Exocytosis Source: FlyBase
Negative regulation of response to wounding Source: FlyBase
Neuron cellular homeostasis Source: FlyBase
Protein folding Source: FlyBase
Regulation of neuromuscular synaptic transmission Source: FlyBase
Regulation of synaptic vesicle cycle Source: SynGO
Synaptic vesicle exocytosis Source: FlyBase
Cellular Location
Membrane
PTM
Fatty acylated. Heavily palmitoylated in the cysteine string motif.

Montero, K. F., Berberian, M. V., Mayorga, L. S., Tomes, C. N., & Ruete, M. C. (2022). The molecular chaperone Cysteine String Protein is required to stabilize trans-SNARE complexes during human sperm acrosomal exocytosis. bioRxiv.

Berberian, M. V., Mayorga, L. S., Tomes, C. N., & Ruete, M. C. (2022). The molecular chaperone Cysteine String Protein is required to stabilize trans-SNARE complexes during human sperm acrosomal exocytosis.

Gundersen, C. B. (2020). Cysteine string proteins. Progress in Neurobiology, 188, 101758.

Nieto-González, J. L., Gómez-Sánchez, L., Mavillard, F., Linares-Clemente, P., Rivero, M. C., Valenzuela-Villatoro, M., ... & Fernández-Chacón, R. (2019). Loss of postnatal quiescence of neural stem cells through mTOR activation upon genetic removal of cysteine string protein-α. Proceedings of the National Academy of Sciences, 116(16), 8000-8009.

Mulcahy, B., Ibbett, P., Holden-Dye, L., & O'connor, V. (2019). The Caenorhabditis elegans cysteine-string protein homologue DNJ-14 is dispensable for neuromuscular junction maintenance across ageing. Journal of Experimental Biology, 222(22), jeb205450.

Valenzuela-Villatoro, M., García-Junco-Clemente, P., Nieto-González, J. L., & Fernández-Chacón, R. (2018). Presynaptic neurodegeneration: CSP-α/DNAJC5 at the synaptic vesicle cycle and beyond. Current Opinion in Physiology, 4, 65-69.

Shirafuji, T., Ueyama, T., Adachi, N., Yoshino, K. I., Sotomaru, Y., Uwada, J., ... & Sakai, N. (2018). The role of cysteine string protein α phosphorylation at serine 10 and 34 by Protein Kinase Cγ for Presynaptic Maintenance. Journal of Neuroscience, 38(2), 278-290.

Deng, J., Koutras, C., Donnelier, J., Alshehri, M., Fotouhi, M., Girard, M., ... & Braun, J. E. (2017). Neurons export extracellular vesicles enriched in cysteine string protein and misfolded protein cargo. Scientific reports, 7(1), 1-12.

Diez-Ardanuy, C., Greaves, J., Munro, K. R., Tomkinson, N. C., & Chamberlain, L. H. (2017). A cluster of palmitoylated cysteines are essential for aggregation of cysteine-string protein mutants that cause neuronal ceroid lipofuscinosis. Scientific reports, 7(1), 1-10.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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