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Mouse Anti-CSRP2 Recombinant Antibody (8C97) (CBMAB-C2974-CN)

This product is a Mouse antibody that recognizes CSRP2. The antibody 8C97 can be used for immunoassay techniques such as: WB.
See all CSRP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
8C97
Application
WB

Basic Information

Immunogen
Partial sequence of recombinant full-length protein to human Cysteine and Glycine-rich Protein 2 Binding Protein
Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 1% BSA
Preservative
0.05% Sodium azide
Concentration
0.1 mg/mL

Target

Full Name
Cysteine And Glycine Rich Protein 2
Introduction
CSRP2 (Cysteine And Glycine Rich Protein 2) is a Protein Coding gene. Diseases associated with CSRP2 include Miller-Dieker Lissencephaly Syndrome. Among its related pathways are Mesodermal Commitment Pathway and Immune response IL-23 signaling pathway. An important paralog of this gene is CSRP1.
Entrez Gene ID
1466
UniProt ID
Q16527
Alternative Names
Cysteine And Glycine Rich Protein 2; Smooth Muscle Cell LIM Protein; LIM Domain Only Protein 5; Cysteine-Rich Protein 2; LMO-5; SmLIM;
Function
Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system.
Biological Process
Actin cytoskeleton organization Source: GO_Central
Cell differentiation Source: UniProtKB
Multicellular organism development Source: UniProtKB-KW
Muscle tissue development Source: GO_Central
Sarcomere organization Source: GO_Central
Cellular Location
Nucleus

Guru, A., Lite, C., Freddy, A. J., Issac, P. K., Pasupuleti, M., Saraswathi, N. T., ... & Arockiaraj, J. (2021). Intracellular ROS scavenging and antioxidant regulation of WL15 from cysteine and glycine-rich protein 2 demonstrated in zebrafish in vivo model. Developmental & Comparative Immunology, 114, 103863.

Wang, S., Zhang, Y., Liu, Y., Zheng, R., Wu, Z., Fan, Y., ... & Liu, Y. (2020). Inhibition of CSRP2 promotes leukemia cell proliferation and correlates with relapse in adults with acute myeloid leukemia. OncoTargets and therapy, 13, 12549.

Chen, L., Long, X., Duan, S., Liu, X., Chen, J., Lan, J., ... & Zhou, J. (2020). CSRP2 suppresses colorectal cancer progression via p130Cas/Rac1 axis-meditated ERK, PAK, and HIPPO signaling pathways. Theranostics, 10(24), 11063.

Brown-Clay, J. D., Hoffman, C., Mao, X., Moreau, F., Marani, V., Casellas, C. P., ... & Thomas, C. (2019). Pro-Metastatic Matrix Metalloproteinase Expression is Induced by the Invadopodial and Cytoskeletal Regulators Glycine-and Cysteine-Rich Proteins 1 and 2. Available at SSRN 3352504.

Hoffmann, C., Mao, X., Brown-Clay, J., Moreau, F., Al Absi, A., Wurzer, H., ... & Thomas, C. (2018). Hypoxia promotes breast cancer cell invasion through HIF-1α-mediated up-regulation of the invadopodial actin bundling protein CSRP2. Scientific reports, 8(1), 1-14.

Kihara, T., Sugimoto, Y., Shinohara, S., Takaoka, S., & Miyake, J. (2017). Cysteine-rich protein 2 accelerates actin filament cluster formation. Plos one, 12(8), e0183085.

Wang, S. J., Wang, P. Z., Gale, R. P., Qin, Y. Z., Liu, Y. R., Lai, Y. Y., ... & Ruan, G. R. (2017). Cysteine and glycine-rich protein 2 (CSRP2) transcript levels correlate with leukemia relapse and leukemia-free survival in adults with B-cell acute lymphoblastic leukemia and normal cytogenetics. Oncotarget, 8(22), 35984.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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