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Mouse Anti-CTDSPL Recombinant Antibody (CBCNC-447) (CBMAB-C3047-CN)

This product is a Mouse antibody that recognizes CTDSPL. The antibody CBCNC-447 can be used for immunoassay techniques such as: ELISA, WB.
See all CTDSPL antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBCNC-447
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Immunogen
Recombinant fragment of human SCP3
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL

Target

Full Name
CTD Small Phosphatase Like
Introduction
CTDSPL (CTD Small Phosphatase Like) is a Protein Coding gene. Among its related pathways are Signaling by BMP and Regulation of cytoplasmic and nuclear SMAD2/3 signaling. Gene Ontology (GO) annotations related to this gene include phosphatase activity and phosphoprotein phosphatase activity. An important paralog of this gene is CTDSP1.
Entrez Gene ID
10217
UniProt ID
O15194
Alternative Names
CTD Small Phosphatase Like; Small CTD Phosphatase 3; CTD (Carboxy-Terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase-Like; Carboxy-Terminal Domain RNA Polymerase II Polypeptide A Small Phosphatase 3; RB Protein Serine Phosphatase From Chromosome 3; Nuclear LIM Interactor-Interacting Factor 1; Small C-Terminal Domain Phosphatase 3; NLI-Interacting Factor 1; NIF-Like Protein; EC 3.1.3.16; CTDSP-Like; C3orf8; HYA22;
Function
Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity).

Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation.
Biological Process
Negative regulation of G1/S transition of mitotic cell cycle Source: Ensembl
Negative regulation of protein phosphorylation Source: Ensembl
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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