Rabbit Anti-CTNNA2 Recombinant Antibody (CBLC285-LY) (CBMAB-C11292-LY)

The product is antibody recognizes CTNNA2. The antibody CBLC285-LY immunoassay techniques such as: WB, IP, ICC.
See all CTNNA2 antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human, Mouse, Rat

Clone

CBLC285-LY

Antibody Isotype

IgG

Application

WB, IP, ICC

Basic Information

Immunogen

A synthetic peptide corresponding to residues in human ?-2 Catenin was used as an immungen

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

50% Glycerol , 0.05% BSA

Preservative

0.01% sodium azide

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Catenin Alpha 2

Introduction

CTNNA2 (Catenin Alpha 2) is a Protein Coding gene. Diseases associated with CTNNA2 include Mixed Germ Cell Cancer. Among its related pathways are Ectoderm Differentiation and PAK Pathway. Gene Ontology (GO) annotations related to this gene include structural molecule activity and structural constituent of cytoskeleton. An important paralog of this gene is CTNNA1.

Entrez Gene ID

Human	1496
Mouse	12386
Rat	297357

UniProt ID

Human	P26232
Mouse	Q61301
Rat	D4A6H8

Alternative Names

Catenin Alpha 2; Catenin (Cadherin-Associated Protein), Alpha 2; Cadherin-Associated Protein, Related; Alpha-Catenin-Related Protein; Cancer/Testis Antigen 114; Alpha-N-Catenin; CAPR;

Function

May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity).

Required for proper regulation of cortical neuronal migration and neurite growth (PubMed:30013181).

It acts as negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed:30013181).

It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed:30013181).

Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity).

Biological Process

Axonogenesis Source: UniProtKB
Brain morphogenesis Source: UniProtKB
Cell-cell adhesion Source: UniProtKB
Cell migration Source: GO_Central
Dendrite morphogenesis Source: UniProtKB
Negative regulation of Arp2/3 complex-mediated actin nucleation Source: UniProtKB
Positive regulation of muscle cell differentiation Source: Reactome
Prepulse inhibition Source: UniProtKB
Radial glia guided migration of Purkinje cell Source: UniProtKB
Regulation of neuron migration Source: UniProtKB
Regulation of neuron projection development Source: UniProtKB
Regulation of synapse structural plasticity Source: UniProtKB

Cellular Location

Nucleus; Cell membrane; Cytoskeleton; Cytoplasm; Adherens junction; Axon

Involvement in disease

Cortical dysplasia, complex, with other brain malformations 9 (CDCBM9):
An autosomal recessive disorder characterized by neurodevelopmental delay apparent from early infancy, acquired microcephaly, hypotonic cerebral palsy, inability to ambulate or speak, and intractable seizures. Brain imaging shows pachygyria with severe cortical gray matter thickening, paucity of gyri without an obvious posterior-anterior gradient or focal dysplasias, hypogenesis of the corpus callosum, and cerebellar hypoplasia.

References

Wen, Y., Lin, A., Zhu, W., Wei, T., Luo, P., Guo, L., & Zhang, J. (2021). Catenin Alpha-2 Mutation Changes the Immune Microenvironment in Lung Adenocarcinoma Patients Receiving Immune Checkpoint Inhibitors. Frontiers in Pharmacology, 12.

Eszlari, N., Bagyura, Z., Millinghoffer, A., Nagy, T., Juhasz, G., Antal, P., ... & Bagdy, G. (2021). Catenin Alpha 2 May Be a Biomarker or Potential Drug Target in Psychiatric Disorders with Perseverative Negative Thinking. Pharmaceuticals, 14(9), 850.

Song, J., Zhang, P., Liu, M., Xie, M., Gao, Z., Wang, X., ... & Liu, R. (2019). Novel-miR-4885 promotes migration and invasion of esophageal Cancer cells through targeting CTNNA2. DNA and cell biology, 38(2), 151-161.

Schaffer, A. E., Breuss, M. W., Caglayan, A. O., Al-Sanaa, N., Al-Abdulwahed, H. Y., Kaymakcalan, H., ... & Gleeson, J. G. (2018). Biallelic loss of human CTNNA2, encoding αN-catenin, leads to ARP2/3 complex overactivity and disordered cortical neuronal migration. Nature genetics, 50(8), 1093-1101.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Antibody Pairs

CTNNA2 Matched Antibody Pair (315)

Related Products

CTNNA2 Matched Antibody Pair (315)

Rabbit Anti-CTNNA2 (Phosphorylated S641) Polyclonal Antibody (PTM-CBPAB-0458YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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