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Mouse Anti-CUL9 Recombinant Antibody (PO69) (CBMAB-P0258-YC)

Provided herein is a Mouse monoclonal antibody against Human Cullin 9. The antibody can be used for immunoassay techniques, such as WB.
See all CUL9 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
PO69
Antibody Isotype
IgG1, κ
Application
WB

Basic Information

Immunogen
Human PARC peptide
Specificity
Human, Mouse
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.2, containing 0.09% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cullin 9
Introduction
CUL9 (Cullin 9) is a protein coding gene. Gene Ontology annotations related to this gene include binding and ubiquitin protein ligase binding. An important paralog of the gene is CUL7.
Entrez Gene ID
Human23113
Mouse78309
UniProt ID
HumanQ8IWT3
MouseQ80TT8
Alternative Names
Cullin 9; P53-Associated Parkin-Like Cytoplasmic Protein; Parkin-Like Cytoplasmic P53 Binding Protein; UbcH7-Associated Protein 1; CUL-9; H7AP1; PARC; Cullin-9; KIAA0708;
Function
Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 (PubMed:24793696).

Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function (PubMed:12526791, PubMed:17332328).
Biological Process
Microtubule cytoskeleton organization Source: UniProtKB
Post-translational protein modification Source: Reactome
Protein ubiquitination Source: UniProtKB
Regulation of mitotic nuclear division Source: UniProtKB
Ubiquitin-dependent protein catabolic process Source: InterPro
Cellular Location
Cytoplasm
PTM
In vitro, self-ubiquitination in the presence of E1, E2 and ubiquitin.
Neddylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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