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Mouse Anti-CUX1 Recombinant Antibody (CBLC205-LY) (CBMAB-C11342-LY)

The product is antibody recognizes CUX1. The antibody CBLC205-LY immunoassay techniques such as: WB, IP, IF, IHC-P, ELISA.
See all CUX1 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBLC205-LY
Antibody Isotype
IgG
Application
WB, IP, IF, IHC-P, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cut Like Homeobox 1
Introduction
CUX1 (Cut Like Homeobox 1) is a Protein Coding gene. Diseases associated with CUX1 include Fiedler's Myocarditis and Dirofilariasis. Among its related pathways are Vesicle-mediated transport and Signaling by FGFR2 in disease. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is CUX2.
Entrez Gene ID
Human1523
Mouse13047
Rat116639
UniProt ID
HumanP39880
MouseP53564
RatP53565
Function
Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator.

CDP/Cux p110:
Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1.
Biological Process
Multicellular organism development Source: ProtInc
Negative regulation of transcription by RNA polymerase II Source: ProtInc
Positive regulation of dendrite morphogenesis Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Retrograde transport, vesicle recycling within Golgi Source: Ensembl
Cellular Location
Nucleus
Involvement in disease
Global developmental delay with or without impaired intellectual development (GDDI):
An autosomal dominant disorder characterized by global developmental delay associated with mild-to-moderate intellectual disability, hypotonia and short stature in some patients.
PTM
Phosphorylated by PKA.
As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa by CTSL. Cell cycle-dependent processing of CUX1 serves to generate a CDP/Cux p110 with distinct DNA binding and transcriptional properties.

Supper, E., Rudat, S., Iyer, V., Droop, A., Wong, K., Spinella, J. F., ... & Wong, C. C. (2021). Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia. Nature communications, 12(1), 1-20.

Yang, F., Hu, A., Guo, Y., Wang, J., Li, D., Wang, X., ... & Tong, Q. (2021). p113 isoform encoded by CUX1 circular RNA drives tumor progression via facilitating ZRF1/BRD4 transactivation. Molecular cancer, 20(1), 1-19.

Yu, L., Zhong, L., Xiong, L., Dan, W., Li, J., Ye, J., ... & Liu, B. (2020). Neutrophil elastase-mediated proteolysis of the tumor suppressor p200 CUX1 promotes cell proliferation and inhibits cell differentiation in APL. Life Sciences, 242, 117229.

Slowikowski, K., Nguyen, H. N., Noss, E. H., Simmons, D. P., Mizoguchi, F., Watts, G. F., ... & Raychaudhuri, S. (2020). CUX1 and IκBζ (NFKBIZ) mediate the synergistic inflammatory response to TNF and IL-17A in stromal fibroblasts. Proceedings of the National Academy of Sciences, 117(10), 5532-5541.

Aly, M., Ramdzan, Z. M., Nagata, Y., Balasubramanian, S. K., Hosono, N., Makishima, H., ... & Maciejewski, J. P. (2019). Distinct clinical and biological implications of CUX1 in myeloid neoplasms. Blood advances, 3(14), 2164-2178.

Li, H., Yang, F., Hu, A., Wang, X., Fang, E., Chen, Y., ... & Tong, Q. (2019). Therapeutic targeting of circ‐CUX 1/EWSR 1/MAZ axis inhibits glycolysis and neuroblastoma progression. EMBO molecular medicine, 11(12), e10835.

Wu, X., Feng, F., Yang, C., Zhang, M., Cheng, Y., Zhao, Y., ... & Heng, X. (2019). Upregulated expression of CUX1 correlates with poor prognosis in glioma patients: a bioinformatic analysis. Journal of Molecular Neuroscience, 69(4), 527-537.

Zhang, M., Wang, Q., Ding, Y., Wang, G., Chu, Y., He, X., ... & Lu, K. (2018). CUX1-ALK, a novel ALK rearrangement that responds to crizotinib in non–small cell lung cancer. Journal of Thoracic Oncology, 13(11), 1792-1797.

Kaur, S., Ramdzan, Z. M., Guiot, M. C., Li, L., Leduy, L., Ramotar, D., ... & Nepveu, A. (2018). CUX1 stimulates APE1 enzymatic activity and increases the resistance of glioblastoma cells to the mono-alkylating agent temozolomide. Neuro-oncology, 20(4), 484-493.

Xu, H., He, J. H., Xu, S. J., Xie, S. J., Ma, L. M., Zhang, Y., ... & Qu, L. H. (2018). A group of tissue‐specific microRNAs contribute to the silencing of CUX1 in different cell lineages during development. Journal of cellular biochemistry, 119(7), 6238-6248.

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For research use only. Not intended for any clinical use.

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