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Rabbit Anti-CXXC5 Recombinant Antibody (D1O4P) (CBMAB-C3257-CN)

This product is a Rabbit antibody that recognizes CXXC5. The antibody D1O4P can be used for immunoassay techniques such as: WB, IP, IF.
See all CXXC5 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey, Cattle, Pig
Clone
D1O4P
Antibody Isotype
IgG
Application
WB, IP, IF

Basic Information

Specificity
Human, Mouse, Rat, Monkey, Cattle, Pig
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
CXXC Finger Protein 5
Introduction
CXXC5 (CXXC Finger Protein 5) is a Protein Coding gene. Diseases associated with CXXC5 include Wilms Tumor 1. Among its related pathways are Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and signal transducer activity. An important paralog of this gene is CXXC4.
Entrez Gene ID
Human51523
Mouse67393
Rat291670
Monkey694746
Cattle538485
Pig100524854
UniProt ID
HumanQ7LFL8
MouseQ91WA4
RatQ5XIQ3
MonkeyQ9P0U4
CattleQ32LB3
PigA0A5G2RI88
Alternative Names
CXXC Finger Protein 5; Retinoid-Inducible Nuclear Factor; Putative NF-Kappa-B-Activating Protein 102; Putative MAPK-Activating Protein PM08; WT1-Induced Inhibitor Of Dishevelled; RINF;
Function
May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity).

Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788).

May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788).

Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034).
Biological Process
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Cellular Location
Nucleus; Cytoplasm. Colocalizes with DVL1 in large bodies localized just outside the nuclear membrane.

Yaşar, P., Kars, G., Yavuz, K., Ayaz, G., Oğuztüzün, Ç., Bilgen, E., ... & Muyan, M. (2021). A CpG island promoter drives the CXXC5 gene expression. Scientific Reports, 11(1), 1-20.

Ayaz, G., Turan, G., Olgun, Ç. E., Kars, G., Karakaya, B., Yavuz, K., ... & Yaşar, P. (2021). A prelude to the proximity interaction mapping of CXXC5. Scientific reports, 11(1), 1-19.

Chen, X., Wang, X., Yi, L., & Song, Y. (2020). The KN motif and ankyrin repeat domains 1/CXXC finger protein 5 axis regulates epithelial-mesenchymal transformation, metastasis and apoptosis of gastric cancer via wnt signaling. OncoTargets and therapy, 13, 7343.

Ayaz, G., Razizadeh, N., Yaşar, P., Kars, G., Kahraman, D. C., Saatci, Ö., ... & Muyan, M. (2020). CXXC5 as an unmethylated CpG dinucleotide binding protein contributes to estrogen-mediated cellular proliferation. Scientific reports, 10(1), 1-14.

Choi, S., Kim, H. Y., Cha, P. H., Seo, S. H., Lee, C., Choi, Y., ... & Choi, K. Y. (2019). CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth. Life science alliance, 2(2).

Xiong, X., Tu, S., Wang, J., Luo, S., & Yan, X. (2019). CXXC5: A novel regulator and coordinator of TGF‐β, BMP and Wnt signaling. Journal of cellular and molecular medicine, 23(2), 740-749.

Fang, L., Wang, Y., Gao, Y., & Chen, X. (2018). Overexpression of CXXC5 is a strong poor prognostic factor in ER+ breast cancer. Oncology Letters, 16(1), 395-401.

Ma, S., Choi, J., Jin, X., Kim, H. Y., Yun, J. H., Lee, W., ... & No, K. T. (2018). Discovery of a small-molecule inhibitor of Dvl–CXXC5 interaction by computational approaches. Journal of Computer-Aided Molecular Design, 32(5), 643-655.

Kim, D., & Garza, L. A. (2017). The negative regulator CXXC5: making WNT look a little less dishevelled. Journal of Investigative Dermatology, 137(11), 2248-2250.

Lee, S. H., Seo, S. H., Lee, D. H., Pi, L. Q., Lee, W. S., & Choi, K. Y. (2017). Targeting of CXXC5 by a competing peptide stimulates hair regrowth and wound-induced hair neogenesis. Journal of Investigative Dermatology, 137(11), 2260-2269.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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