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Mouse Anti-CYBA Recombinant Antibody (CS9) (CBMAB-P0261-YC)

Provided herein is a Mouse monoclonal antibody against Human Cytochrome b-245 alpha chain. The antibody can be used for immunoassay techniques, such as ELISA, FC, IHC-Fr, IP, WB.
See all CYBA antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CS9
Antibody Isotype
IgG1
Application
ELISA, FC, IHC-Fr, IP, WB

Basic Information

Immunogen
p22phox solubilised in octyl-beta-gluycopyranoside
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, 0.09% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cytochrome B-245 Alpha Chain
Introduction
Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes.
Entrez Gene ID
1535
UniProt ID
P13498
Alternative Names
p22-PHOX
Function
Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.
Biological Process
Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
Cell redox homeostasis Source: Reactome
Cellular response to oxidative stress Source: Reactome
Cytochrome complex assembly Source: BHF-UCL
Hydrogen peroxide biosynthetic process Source: BHF-UCL
Inflammatory response Source: BHF-UCL
Innate immune response Source: BHF-UCL
Neutrophil degranulation Source: Reactome
Positive regulation of cell killing Source: Reactome
Positive regulation of defense response to bacterium Source: UniProtKB
Positive regulation of interleukin-6 production Source: UniProtKB
Positive regulation of phagocytosis Source: UniProtKB
Positive regulation of reactive oxygen species biosynthetic process Source: UniProtKB
Positive regulation of toll-like receptor 2 signaling pathway Source: UniProtKB
Positive regulation of tumor necrosis factor production Source: UniProtKB
Respiratory burst Source: BHF-UCL
Smooth muscle hypertrophy Source: BHF-UCL
Superoxide anion generation Source: BHF-UCL
Superoxide metabolic process Source: BHF-UCL
Vascular endothelial growth factor receptor signaling pathway Source: Reactome
Cellular Location
Cell membrane. As unassembled monomer may localize to the endoplasmic reticulum.
Involvement in disease
Granulomatous disease, chronic, cytochrome-b-negative, autosomal recessive (ARCGD):A form of chronic granulomatous disease, a primary immunodeficiency characterized by severe recurrent bacterial and fungal infections, along with manifestations of chronic granulomatous inflammation. It results from an impaired ability of phagocytes to mount a burst of reactive oxygen species in response to pathogens.
PTM
The heme prosthetic group could be coordinated with residues of the light chain, the heavy chain, or both, and it is possible that more than one heme is present per cytochrome b-245.
Phosphorylation at Thr-147 enhances NADPH oxidase activity by promoting p47phox binding.
Ubiquitinated at Lys-149 likely by RNF145.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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