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Mouse Anti-CYBC1 Recombinant Antibody (CBXC-2162) (CBMAB-C5676-CQ)

This product is a mouse antibody that recognizes C17orf62. The antibody CBXC-2162 can be used for immunoassay techniques such as: WB, IF.
See all CYBC1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-2162
Antibody Isotype
IgG1
Application
WB, IF

Basic Information

Immunogen
Full length human recombinant protein of human C17orf62 (NP_001028218)
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CYBC1
Introduction
C17orf62 (Chromosome 17 Open Reading Frame 62) is a Protein Coding gene.
Entrez Gene ID
79415
UniProt ID
Q9BQA9
Alternative Names
Chromosome 17 Open Reading Frame 62;
Function
Functions as a chaperone necessary for a stable expression of the CYBA and CYBB subunits of the cytochrome b-245 heterodimer (PubMed:30361506).

Controls the phagocyte respiratory burst and is essential for innate immunity (By similarity).
Biological Process
Innate immune response Source: UniProtKB
Respiratory burst after phagocytosis Source: UniProtKB
Cellular Location
Endoplasmic reticulum membrane
Involvement in disease
Granulomatous disease, chronic, autosomal recessive, 5 (CGD5):
A form of chronic granulomatous disease, a primary immunodeficiency characterized by severe recurrent bacterial and fungal infections, along with manifestations of chronic granulomatous inflammation. It results from an impaired ability of phagocytes to mount a burst of reactive oxygen species in response to pathogens. CGD5 is an autosomal recessive form characterized by onset of recurrent infections and severe colitis in the first decade of life. Clinical manifestations include increased susceptibility to catalase-positive organisms, features of inflammatory bowel disease, lymphopenia, lymphadenitis, and autoinflammatory symptoms in some patients.
Topology
Helical: 20-42
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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