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Rabbit Anti-CYC1 Recombinant Antibody (EG880) (CBMAB-EN1050-LY)

The product is antibody recognizes CYC1. The antibody EG880 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:20000.
See all CYC1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
EG880
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:20000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human CYC1.
Specificity
Human, Mouse
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cytochrome C1
Introduction
CYC1 (Cytochrome C1) is a Protein Coding gene. Diseases associated with CYC1 include Mitochondrial Complex Iii Deficiency, Nuclear Type 6 and Isolated Complex Iii Deficiency. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism. Gene Ontology (GO) annotations related to this gene include iron ion binding and electron transfer activity.
Entrez Gene ID
Human1537
Mouse66445
UniProt ID
HumanP08574
MouseQ9D0M3
Alternative Names
Cytochrome C1; Ubiquinol-Cytochrome-C Reductase Complex Cytochrome C1 Subunit; Cytochrome B-C1 Complex Subunit 4; Complex III Subunit IV; Complex III Subunit 4; Cytochrome C-1; Cytochrome C1, Heme Protein, Mitochondrial; MC3DN6; UQCR4;
Function
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. Cytochrome c1 is a catalytic core subunit containing a c-type heme. It transfers electrons from the [2Fe-2S] iron-sulfur cluster of the Rieske protein to cytochrome c.
Biological Process
Mitochondrial electron transport, ubiquinol to cytochrome c Source: GO_Central
Response to glucagon Source: Ensembl
Cellular Location
Mitochondrion inner membrane
Involvement in disease
Mitochondrial complex III deficiency, nuclear 6 (MC3DN6):
An autosomal recessive disorder caused by mitochondrial dysfunction. It is characterized by onset in early childhood of episodic acute lactic acidosis, ketoacidosis, and insulin-responsive hyperglycemia, usually associated with infection. Laboratory studies show decreased activity of mitochondrial complex III. Psychomotor development is normal.
Topology
Mitochondrial intermembrane: 85-281
Helical: 282-315
Mitochondrial matrix: 316-325

Heidari, E., Rasoulinezhad, M., Pak, N., Ashrafi, M. R., Heidari, M., Banwell, B., ... & Tavasoli, A. R. (2021). Defective complex III mitochondrial respiratory chain due to a novel variant in CYC1 gene masquerades acute demyelinating syndrome or Leber hereditary optic neuropathy. Mitochondrion, 60, 12-20.

Toth, A., Aufschnaiter, A., Fedotovskaya, O., Dawitz, H., Ädelroth, P., Büttner, S., & Ott, M. (2020). Membrane-tethering of cytochrome c accelerates regulated cell death in yeast. Cell death & disease, 11(9), 1-16.

Bukhari, S. H., Mobeen, I., Naureen, U., Akram, F., Arif, R., Shahid, M. G., & Saleem, M. (2020). Analysis of Genetic Polymorphisms and Post Translational Modifications of Cytochrome C-1 in Sordaria fimicola. Intl J Agric Biol, 23, 675-680.

Sato, A., Takagi, K., Miki, Y., Yoshimura, A., Hara, M., Ishida, T., ... & Suzuki, T. (2019). Cytochrome c1 as a favorable prognostic marker in estrogen receptor-positive breast carcinoma. Histology and Histopathology, 34(12), 1365-1375.

Unni, S., Thiyagarajan, S., Srinivas Bharath, M. M., & Padmanabhan, B. (2019). Tryptophan oxidation in the UQCRC1 subunit of mitochondrial complex III (ubiquinol-cytochrome C reductase) in a mouse model of myodegeneration causes large structural changes in the complex: a molecular dynamics simulation study. Scientific reports, 9(1), 1-13.

Fan, L., Zhu, C., Qiu, R., Zan, P., Zheng, Z., Xu, T., & Li, G. (2017). MicroRNA-661 enhances TRAIL or STS induced osteosarcoma cell apoptosis by modulating the expression of cytochrome c1. Cellular Physiology and Biochemistry, 41(5), 1935-1946.

Chishiki, M., Takagi, K., Sato, A., Miki, Y., Yamamoto, Y., Ebata, A., ... & Suzuki, T. (2017). Cytochrome c1 in ductal carcinoma in situ of breast associated with proliferation and comedo necrosis. Cancer science, 108(7), 1510-1519.

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For research use only. Not intended for any clinical use.

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