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Mouse Anti-CYGB Recombinant Antibody (1A1) (CBMAB-C3498-LY)

This product is antibody recognizes CYGB . The antibody 1A1 immunoassay techniques such as: ELISA, IF, IHC-F, WB.
See all CYGB antibodies
Published Data
Fig.1 Patient's external capsule. Fewer immunoreactive swollen nuclei in serial section of same area, but this was variable between runs with different antibody dilutions.
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Fig.2 Effect of SH or IH on Ngb and Cygb protein expression in rat cortex.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
1A1
Antibody Isotype
IgG1, κ
Application
ELISA, IF, IHC-F, WB

Basic Information

Immunogen
Full length recombinant corresponding to aa1-191 from human CYGB (AAH29798) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cytoglobin
Introduction
CYGB (Cytoglobin) is a Protein Coding gene. Diseases associated with CYGB include Ancylostomiasis. Among its related pathways are Metabolism and eNOS activation and regulation. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxygen binding. An important paralog of this gene is MB.
Entrez Gene ID
114757
UniProt ID
Q8WWM9
Alternative Names
Cytoglobin; Stellate Cell Activation-Associated Protein; Histoglobin; STAP; HGB;
Function
May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer.
Biological Process
Oxygen transport Source: Reactome
Regulation of nitric-oxide synthase activity Source: Reactome
Response to oxidative stress Source: UniProtKB
Cellular Location
Cytoplasm

Zweier, J. L., Hemann, C., Kundu, T., Ewees, M. G., Khaleel, S. A., Samouilov, A., ... & El-Mahdy, M. A. (2021). Cytoglobin has potent superoxide dismutase function. Proceedings of the National Academy of Sciences, 118(52).

Dat, N. Q., Thuy, L. T. T., Hieu, V. N., Hai, H., Hoang, D. V., Thi Thanh Hai, N., ... & Kawada, N. (2021). Hexa Histidine–Tagged Recombinant Human Cytoglobin Deactivates Hepatic Stellate Cells and Inhibits Liver Fibrosis by Scavenging Reactive Oxygen Species. Hepatology, 73(6), 2527-2545.

De Backer, J., Maric, D., Bosman, M., Dewilde, S., & Hoogewijs, D. (2021). A reliable set of reference genes to normalize oxygen-dependent cytoglobin gene expression levels in melanoma. Scientific reports, 11(1), 1-11.

Zweier, J. L., & Ilangovan, G. (2020). Regulation of nitric oxide metabolism and vascular tone by cytoglobin. Antioxidants & Redox Signaling, 32(16), 1172-1187.

Le Thi Thanh Thuy, H. H., & Kawada, N. (2020). Role of cytoglobin, a novel radical scavenger, in stellate cell activation and hepatic fibrosis. Clinical and molecular hepatology, 26(3), 280.

Okina, Y., Sato-Matsubara, M., Matsubara, T., Daikoku, A., Longato, L., Rombouts, K., ... & Kawada, N. (2020). TGF-β1-driven reduction of cytoglobin leads to oxidative DNA damage in stellate cells during non-alcoholic steatohepatitis. Journal of hepatology, 73(4), 882-895.

De Backer, J., Razzokov, J., Hammerschmid, D., Mensch, C., Hafideddine, Z., Kumar, N., ... & Dewilde, S. (2018). The effect of reactive oxygen and nitrogen species on the structure of cytoglobin: A potential tumor suppressor. Redox biology, 19, 1-10.

Jourd’heuil, F. L., Xu, H., Reilly, T., McKellar, K., El Alaoui, C., Steppich, J., ... & Jourd’heuil, D. (2017). The hemoglobin homolog cytoglobin in smooth muscle inhibits apoptosis and regulates vascular remodeling. Arteriosclerosis, thrombosis, and vascular biology, 37(10), 1944-1955.

Xu, Z. J., Shu, S., Li, Z. J., Liu, Y. M., Zhang, R. Y., & Zhang, Y. (2017). Liuwei Dihuang pill treats diabetic nephropathy in rats by inhibiting of TGF-β/SMADS, MAPK, and NF-kB and upregulating expression of cytoglobin in renal tissues. Medicine, 96(3).

Liu, X., El-Mahdy, M. A., Boslett, J., Varadharaj, S., Hemann, C., Abdelghany, T. M., ... & Zweier, J. L. (2017). Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall. Nature communications, 8(1), 1-14.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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