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Mouse Anti-CYP27C1 Recombinant Antibody (V29-P4B8/B2) (CBMAB-C1169-CQ)

This product is a mouse antibody that recognizes CYP27C1. The antibody V29-P4B8/B2 can be used for immunoassay techniques such as: WB, ELISA, IHC.
See all CYP27C1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V29-P4B8/B2
Antibody Isotype
IgG1, κ
Application
WB, ELISA, IHC

Basic Information

Immunogen
Ovalbumin-conjugated synthetic peptide KVVLAPETGEL (C-terminal sequence)
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cytochrome P450 Family 27 Subfamily C Member 1
Introduction
CYP27C1 (Cytochrome P450 Family 27 Subfamily C Member 1) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP27B1.
Entrez Gene ID
339761
UniProt ID
Q4G0S4
Alternative Names
Cytochrome P450 Family 27 Subfamily C Member 1; Cytochrome P450, Family 27, Subfamily C, Polypeptide 1; All-Trans Retinol 3,4-Desaturase; EC 1.14.19.-;
Function
Isoform 2:
A cytochrome P450 monooxygenase that catalyzes the 3,4 desaturation of all-trans-retinol (also called vitamin A1) to all-trans-3,4-didehydroretinol (also called vitamin A2) in the skin. Desaturates with lower efficiency all-trans retinal and all-trans retinoic acid. Forms minor amounts of 3-hydroxy and 4-hydroxy all-trans-retinol derivatives. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).
Biological Process
Retinal metabolic process Source: UniProtKB
Retinoic acid metabolic process Source: UniProtKB
Retinol metabolic process Source: UniProtKB
Cellular Location
Isoform 2: Mitochondrion membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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