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Rabbit Anti-CYP2A13 Recombinant Antibody (EG891) (CBMAB-EN1062-LY)

The product is antibody recognizes CYP2A13. The antibody EG891 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:20000.
See all CYP2A13 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG891
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:20000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human Cytochrome P450 2A13.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cytochrome P450 Family 2 Subfamily A Member 13
Introduction
CYP2A13 (Cytochrome P450 Family 2 Subfamily A Member 13) is a Protein Coding gene. Diseases associated with CYP2A13 include Acetaminophen Metabolism. Among its related pathways are Acetaminophen Pathway (therapeutic doses), Pharmacokinetics and Metabolism. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP2A6.
Entrez Gene ID
1553
UniProt ID
Q16696
Alternative Names
Cytochrome P450 Family 2 Subfamily A Member 13; Cytochrome P450, Subfamily IIA (Phenobarbital-Inducible), Polypeptide 13; Cytochrome P450, Family 2, Subfamily A, Polypeptide 13; EC 1.14.14.1; CYPIIA13; Cytochrome P450 2A13; CYP2A; CPAD;
Function
Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N-dimethylaniline, 2'-methoxyacetophenone, N-nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity.
Biological Process
Aflatoxin metabolic process Source: Reactome
Coumarin metabolic process Source: GO_Central
Epoxygenase P450 pathway Source: GO_Central
Exogenous drug catabolic process Source: GO_Central
Organic acid metabolic process Source: GO_Central
Xenobiotic metabolic process Source: GO_Central
Cellular Location
Endoplasmic reticulum membrane; Microsome membrane

Juvonen, R. O., Jokinen, E. M., Huuskonen, J., Kärkkäinen, O., Raunio, H., & Pentikäinen, O. T. (2021). Molecular docking and oxidation kinetics of 3-phenyl coumarin derivatives by human CYP2A13. Xenobiotica, 51(11), 1207-1216.

Vrzal, R. (2021). Genetic and Enzymatic Characteristics of CYP2A13 in Relation to Lung Damage. International Journal of Molecular Sciences, 22(22), 12306.

Soeroso, N., Zain-Hamid, R., Bihar, S., Tarigan, S. P., & Ananda, F. R. (2021). Genetic Polymorphism of Cyp2a6 and Cyp2a13 Genes and Environmental Tobacco Smoke Induced Lung Cancer Risk in Indonesian Female Never Smokers. Open Access Macedonian Journal of Medical Sciences, 9(A), 1219-1225.

Ma, L., Jin, G., Yang, Y., Pang, Y., Wang, W., Zhang, H., ... & Zhu, Z. (2020). Association between CYP2A13 polymorphisms and lung cancer: A protocol for systematic review and meta-analysis. Medicine, 99(50).

Boonruang, S., Prakobsri, K., Pouyfung, P., Prasopthum, A., Rongnoparut, P., & Sarapusit, S. (2020). Structure–activity relationship and in vitro inhibition of human cytochrome CYP2A6 and CYP2A13 by flavonoids. Xenobiotica, 50(6), 630-639.

Hua, F., Guo, Y., Sun, Q., Yang, L., & Gao, F. (2019). HapMap‐based study: CYP2A13 may be a potential key metabolic enzyme gene in the carcinogenesis of lung cancer in non‐smokers. Thoracic Cancer, 10(4), 601-606.

Kovalchuk, N., Zhang, Q. Y., Kelty, J., Van Winkle, L., & Ding, X. (2019). Toxicokinetic interaction between hepatic disposition and pulmonary bioactivation of inhaled naphthalene studied using Cyp2abfgs-null and CYP2A13/2F1-humanized mice with deficient hepatic cytochrome P450 activity. Drug Metabolism and Disposition, 47(12), 1469-1478.

Shimada, T., Murayama, N., Kakimoto, K., Takenaka, S., Lim, Y. R., Yeom, S., ... & Komori, M. (2018). Oxidation of 1-chloropyrene by human CYP1 family and CYP2A subfamily cytochrome P450 enzymes: catalytic roles of two CYP1B1 and five CYP2A13 allelic variants. Xenobiotica, 48(6), 565-575.

Kumondai, M., Hosono, H., Maekawa, M., Yamaguchi, H., Mano, N., Oda, A., ... & Hiratsuka, M. (2018). Functional characterization of 9 CYP2A13 allelic variants by assessment of nicotine C-oxidation and coumarin 7-hydroxylation. Drug metabolism and pharmacokinetics, 33(1), 82-89.

Li, L., Carratt, S., Hartog, M., Kovalchuk, N., Jia, K., Wang, Y., ... & Ding, X. (2017). Human CYP2A13 and CYP2F1 mediate naphthalene toxicity in the lung and nasal mucosa of CYP2A13/2F1-humanized mice. Environmental health perspectives, 125(6), 067004.

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For research use only. Not intended for any clinical use.

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