Sign in or Register   Sign in or Register
  |  

Mouse Anti-CYP2W1 Recombinant Antibody (CBWJC-3571) (CBMAB-C4805WJ)

This product is a Mouse antibody that recognizes CYP2W1. This antibody CBWJC-3571 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all CYP2W1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJC-3571
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cytochrome P450 Family 2 Subfamily W Member 1
Introduction
CYP2W1 (Cytochrome P450 Family 2 Subfamily W Member 1) is a Protein Coding gene. Among its related pathways are Metabolism and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP2D6.
Entrez Gene ID
54905
UniProt ID
Q8TAV3
Alternative Names
Cytochrome P450 Family 2 Subfamily W Member 1; Cytochrome P450, Family 2, Subfamily W, Polypeptide 1; CYPIIW1; Cytochrome P450 2W1; EC 1.14.14.1; EC 1.14.14.5; EC 1.14.14.-;
Function
A cytochrome P450 monooxygenase that may play a role in retinoid and phospholipid metabolism (PubMed:22591743, PubMed:26936974).

Catalyzes the hydroxylation of saturated carbon hydrogen bonds. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may regulate atRA clearance. Other retinoids such as all-trans retinol and all-trans retinal are potential endogenous substrates (PubMed:26936974).

Catalyzes both epoxidation of double bonds and hydroxylation of carbon hydrogen bonds of the fatty acyl chain of 1-acylphospholipids/2-lysophospholipids. Can metabolize various lysophospholipids classes including lysophosphatidylcholines (LPCs), lysophosphatidylinositols (LPIs), lysophosphatidylserines (LPSs), lysophosphatidylglycerols (LPGs), lysophosphatidylethanolamines (LPEs) and lysophosphatidic acids (LPAs) (PubMed:22591743).

Has low or no activity toward 2-acylphospholipids/1-lysophospholipids, diacylphospholipids and free fatty acids (PubMed:26936974, PubMed:22591743).

May play a role in tumorigenesis by activating procarcinogens such as aflatoxin B1, polycyclic aromatic hydrocarbon dihydrodiols and aromatic amines (PubMed:20805301, PubMed:16551781, PubMed:24278521).

Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:22591743, PubMed:26936974).
Biological Process
Aflatoxin metabolic process Source: UniProtKB
Exogenous drug catabolic process Source: GO_Central
Organic acid metabolic process Source: GO_Central
Phospholipid metabolic process Source: UniProtKB
Retinoic acid catabolic process Source: UniProtKB
Xenobiotic metabolic process Source: UniProtKB
Cellular Location
Cell membrane; Endoplasmic reticulum lumen; Microsome membrane. About 8% are expressed on the cell surface.

Altieri, B., Sbiera, S., Herterich, S., De Francia, S., Della Casa, S., Calabrese, A., ... & Ronchi, C. L. (2020). Effects of germline CYP2W1* 6 and CYP2B6* 6 single nucleotide polymorphisms on mitotane treatment in adrenocortical carcinoma: a multicenter ENSAT study. Cancers, 12(2), 359.

Ronis, M. J., Mercer, K. E., Shankar, K., Pulliam, C., Pedersen, K., Ingelman-Sundberg, M., ... & Welsh, D. A. (2020). Potential role of gut microbiota, the proto-oncogene PIKE (Agap2) and cytochrome P450 CYP2W1 in promotion of liver cancer by alcoholic and nonalcoholic fatty liver disease and protection by dietary soy protein. Chemico-biological interactions, 325, 109131.

Szaefer, H., Licznerska, B., Cykowiak, M., & Baer-Dubowska, W. (2019). Expression of CYP2S1 and CYP2W1 in breast cancer epithelial cells and modulation of their expression by synthetic methoxy stilbenes. Pharmacological Reports, 71(6), 1001-1005.

Altieri, B., Herterich, S., Volante, M., Sbiera, S., De, F. S., Della Casa, S., ... & Ronchi, C. L. (2018, May). Germline CYP2W1* 6 polymorphism is a new predictive marker of sensitivity to mitotane treatment in advanced adrenocortical carcinoma: a multicenter European study. In Endocrine Abstracts (Vol. 56). Bioscientifica.

Altieri, B., Herterich, S., Sbiera, S., Volante, M., Kroiss, M., Della Casa, S., ... & Ronchi, C. L. (2017, May). CYP2W1* 6 polymorphism as a potential predictive marker of sensitivity to mitotane treatment in adrenocortical carcinoma. In Endocrine Abstracts (Vol. 49). Bioscientifica.

Pan, Y., & Ong, E. C. (2017). Cytochrome P450 2W1 (CYP2W1)–ready for use as the biomarker and drug target for cancer?. Xenobiotica, 47(10), 923-932.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-CYP2W1 Recombinant Antibody (CBWJC-3571)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare