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Rabbit Anti-CYP39A1 Recombinant Antibody (EG904) (CBMAB-EN1075-LY)

The product is antibody recognizes CYP39A1. The antibody EG904 immunoassay techniques such as: WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:10000.
See all CYP39A1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
EG904
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:10000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human Cytochrome P450 39A1.
Specificity
Human, Mouse
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cytochrome P450 Family 39 Subfamily A Member 1
Introduction
CYP39A1 (Cytochrome P450 Family 39 Subfamily A Member 1) is a Protein Coding gene. Among its related pathways are Metabolism and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP8B1.
Entrez Gene ID
Human51302
Mouse56050
UniProt ID
HumanQ9NYL5
MouseQ9JKJ9
Alternative Names
Cytochrome P450 Family 39 Subfamily A Member 1; Cytochrome P450, Subfamily XXXIX (Oxysterol 7 Alpha-Hydroxylase), Polypeptide 1; Cytochrome P450, Family 39, Subfamily A, Polypeptide 1; Oxysterol 7-Alpha-Hydroxylase; Cytochrome P450 39A1; EC 1.14.14.26; HCYP39A1;
Function
A cytochrome P450 monooxygenase involved in neural cholesterol clearance through bile acid synthesis (PubMed:25201972, PubMed:10748047).

Catalyzes 7-alpha hydroxylation of (24S)-hydroxycholesterol, a neural oxysterol that is metabolized to bile acids in the liver (PubMed:25201972, PubMed:10748047).

Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:25201972, PubMed:10748047).
Biological Process
Bile acid biosynthetic process Source: UniProtKB
Cholesterol catabolic process Source: UniProtKB-UniPathway
Cholesterol homeostasis Source: GO_Central
Digestion Source: UniProtKB
Sterol metabolic process Source: Reactome
Cellular Location
Endoplasmic reticulum membrane; Microsome membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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