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Recombinant Mouse Anti-CYP4A11 Recombinant Antibody (P2A10) (CBMAB-XB0329-YC)

Provided herein is a Mouse Recombinant Antibody against Cytochrome P450 Family 4 Subfamily A Member 11. The antibody can be used for immunoassay techniques, such as ELISA, IHC, WB.
See all CYP4A11 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Drosophila, Mouse, Rat, Frog
Clone
P2A10
Antibody Isotype
IgG1, κ
Application
ELISA, IHC, WB

Basic Information

Immunogen
Peptide sequence-KNGIHLRLR (amino acids 499-507)
Specificity
Human, Drosophila, Mouse, Rat, Frog
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cytochrome P450 Family 4 Subfamily A Member 11
Introduction
CYP4A11 (Cytochrome P450 Family 4 Subfamily A Member 11) is a protein coding gene. Diseases associated with CYP4A11 include Generalized Atherosclerosis and Hypertensive Nephropathy. Among its related pathways are Arachidonic acid metabolism and Constitutive Androstane Receptor Pathway. Gene Ontology annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP4A22.
Entrez Gene ID
Human1579
Rat24306
UniProt ID
HumanQ02928
RatP20816
Alternative Names
Cytochrome P450 Family 4 Subfamily A Member 11; Cytochrome P450, Family 4, Subfamily A, Polypeptide 11; Cytochrome P450, Subfamily IVA, Polypeptide 11; Long-Chain Fatty Acid Omega-Monooxygenase; 20-Hydroxyeicosatetraenoic Acid Synthase; Lauric Acid Omega-Hydroxylase; Fatty Acid Omega-Hydroxylase; Cytochrome P-450HK-Omega; Cytochrome P450HL-Omega; 20-HETE Synthase;
Function
A cytochrome P450 monooxygenase involved in the metabolism of fatty acids and their oxygenated derivatives (oxylipins) (PubMed:7679927, PubMed:1739747, PubMed:8914854, PubMed:10553002, PubMed:10660572, PubMed:15611369).

Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:7679927, PubMed:1739747, PubMed:8914854, PubMed:10553002, PubMed:10660572, PubMed:15611369).

Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of saturated and unsaturated fatty acids, the catalytic efficiency decreasing in the following order: dodecanoic> tetradecanoic> (9Z)-octadecenoic> (9Z,12Z)-octadecadienoic> hexadecanoic acid (PubMed:10553002, PubMed:10660572).

Acts as a major omega-hydroxylase for dodecanoic (lauric) acid in liver (PubMed:7679927, PubMed:1739747, PubMed:8914854, PubMed:15611369).

Participates in omega-hydroxylation of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) to 20-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PubMed:10620324, PubMed:10660572, PubMed:15611369).

Can also catalyze the oxidation of the penultimate carbon (omega-1 oxidation) of fatty acids with lower efficiency (PubMed:7679927).

May contribute to the degradation of saturated very long-chain fatty acids (VLCFAs) such as docosanoic acid, by catalyzing successive omega-oxidations to the corresponding dicarboxylic acid, thereby initiating chain shortening (PubMed:18182499).

Omega-hydroxylates (9R,10S)-epoxy-octadecanoate stereoisomer (PubMed:15145985).

Plays a minor role in omega-oxidation of long-chain 3-hydroxy fatty acids (PubMed:18065749).

Has little activity toward prostaglandins A1 and E1 (PubMed:7679927).
Biological Process
Arachidonic acid metabolic process Source: UniProtKB
Epoxygenase P450 pathway Source: UniProtKB
Fatty acid metabolic process Source: Reactome
Icosanoid biosynthetic process Source: GO_Central
Kidney development Source: GO_Central
Lauric acid metabolic process Source: GO_Central
Leukotriene metabolic process Source: UniProtKB
Linoleic acid metabolic process Source: GO_Central
Long-chain fatty acid metabolic process Source: BHF-UCL
Omega-hydroxylase P450 pathway Source: Reactome
Oxylipin biosynthetic process Source: UniProtKB-UniPathway
Positive regulation of icosanoid secretion Source: UniProtKB
Pressure natriuresis Source: UniProtKB
Regulation of metabolic process Source: Reactome
Renal water homeostasis Source: UniProtKB
Sodium ion homeostasis Source: UniProtKB
Cellular Location
Endoplasmic reticulum membrane; Microsome membrane

Gao, H., Cao, Y., Xia, H., Zhu, X., & Jin, Y. (2020). CYP4A11 is involved in the development of nonalcoholic fatty liver disease via ROS‑induced lipid peroxidation and inflammation. International journal of molecular medicine, 45(4), 1121-1129.

Han, L., Zhang, H., Zeng, Y., Lv, Y., Tao, L., Ma, J., ... & Chen, L. (2020). Identification of the miRNA-3185/CYP4A11 axis in cardiac tissue as a biomarker for mechanical asphyxia. Forensic Science International, 311, 110293.

Kim, S., Kim, J. M., Lee, H. J., Lim, J. S., Seong, I. O., & Kim, K. H. (2020). Alteration of CYP4A11 expression in renal cell carcinoma: diagnostic and prognostic implications. Journal of Cancer, 11(6), 1478.

Borin, T. F., Ali, S., Angara, K., Rashid, M., Myers, S., Chawla, D., ... & Arbab, A. S. (2019). CYP4A11 overexpression increases aggressiveness in glioblastoma and breast cancer.

Yu, K., Zhang, T., & Li, X. (2018). Genetic role of CYP4A11 polymorphisms in the risk of developing cardiovascular and cerebrovascular diseases. Annals of Human Genetics, 82(6), 370-381.

Sirotina, S., Ponomarenko, I., Kharchenko, A., Bykanova, M., Bocharova, A., Vagaytseva, K., ... & Polonikov, A. (2018). A novel polymorphism in the promoter of the CYP4A11 gene is associated with susceptibility to coronary artery disease. Disease Markers, 2018.

Yamaori, S., Araki, N., Shionoiri, M., Ikehata, K., Kamijo, S., Ohmori, S., & Watanabe, K. (2018). A specific probe substrate for evaluation of CYP4A11 activity in human tissue microsomes and a highly Selective CYP4A11 inhibitor: luciferin-4A and epalrestat. Journal of Pharmacology and Experimental Therapeutics, 366(3), 446-457.

Yang, M., Lv, J., Zhang, L., Li, M., Zhou, Y., Lan, X., ... & Chen, H. (2017). Association study and expression analysis of CYP4A11 gene copy number variation in Chinese cattle. Scientific reports, 7(1), 1-8.

Zhang, H., Jin, L., Mu, T., Fan, Y., Zhang, H., Zhu, Y., ... & Tang, S. (2017). Associations of CYP4A11 gene–gene and gene–smoking interactions with essential hypertension in the male eastern Chinese Han population. Clinical and Experimental Hypertension, 39(5), 448-453.

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For research use only. Not intended for any clinical use.

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