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Rabbit Anti-CYP4B1 Recombinant Antibody (EG908) (CBMAB-EN1079-LY)

The product is antibody recognizes CYP4B1. The antibody EG908 immunoassay techniques such as: WB: 1:500~1:1000 IHC: 1:50~1:100 ELISA: 1:40000.
See all CYP4B1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG908
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 IHC: 1:50~1:100 ELISA: 1:40000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human Cytochrome P450 4B1.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cytochrome P450 Family 4 Subfamily B Member 1
Introduction
CYP4B1 (Cytochrome P450 Family 4 Subfamily B Member 1) is a Protein Coding gene. Diseases associated with CYP4B1 include Bladder Cancer. Among its related pathways are Arachidonic acid metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP4A11.
Entrez Gene ID
1580
UniProt ID
P13584
Alternative Names
Cytochrome P450 Family 4 Subfamily B Member 1; Cytochrome P450, Family 4, Subfamily B, Polypeptide 1; Cytochrome P450, Subfamily IVB, Polypeptide 1; Cytochrome P450-HP; EC 1.14.14.1; CYPIVB1; Microsomal Monooxygenase; Cytochrome P450 4B1; P-450HP;
Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Biological Process
Biphenyl metabolic process Source: Ensembl
Fatty acid metabolic process Source: Reactome
Cellular Location
Endoplasmic reticulum membrane; Microsome membrane

Liu, X., Jia, Y., Shi, C., Kong, D., Wu, Y., Zhang, T., ... & Wang, D. (2021). CYP4B1 is a prognostic biomarker and potential therapeutic target in lung adenocarcinoma. Plos one, 16(2), e0247020.

Reddy, M., Chaudhuri, T., Rangaswamy, B. E., & Manokaran, S. (2021). Role of rare mutation in UTR region of human CYP4B1, GMPPB gene in Tuberculosis infection. SPAST Abstracts, 1(01).

Lim, S. Y. M., Alshagga, M., Ong, C. E., Chieng, J. Y., & Pan, Y. (2020). Cytochrome P450 4B1 (CYP4B1) as a target in cancer treatment. Human & experimental toxicology, 39(6), 785-796.

Thesseling, F. A., Hutter, M. C., Wiek, C., Kowalski, J. P., Rettie, A. E., & Girhard, M. (2020). Novel insights into oxidation of fatty acids and fatty alcohols by cytochrome P450 monooxygenase CYP4B1. Archives of biochemistry and biophysics, 679, 108216.

Kowalski, J. P., McDonald, M. G., Whittington, D., Guttman, M., Scian, M., Girhard, M., ... & Rettie, A. E. (2019). Structure–Activity Relationships for CYP4B1 Bioactivation of 4-Ipomeanol Congeners: Direct Correlation between Cytotoxicity and Trapped Reactive Intermediates. Chemical Research in Toxicology, 32(12), 2488-2498.

Wang, S., Chen, X., Wang, M., Yao, D., Chen, T., Yan, Q., & Lu, W. (2018). Long non-coding RNA CYP4B1-PS1-001 inhibits proliferation and fibrosis in diabetic nephropathy by interacting with nucleolin. Cellular Physiology and Biochemistry, 49(6), 2174-2187.

Roellecke, K., Jäger, V. D., Gyurov, V. H., Kowalski, J. P., Mielke, S., Rettie, A. E., ... & Girhard, M. (2017). Ligand characterization of CYP4B1 isoforms modified for high-level expression in Escherichia coli and HepG2 cells. Protein Engineering, Design and Selection, 30(3), 207-218.

Hsu, M. H., Baer, B. R., Rettie, A. E., & Johnson, E. F. (2017). The Crystal Structure of Cytochrome P450 4B1 (CYP4B1) Monooxygenase Complexed with Octane Discloses Several Structural Adaptations for ω-Hydroxylation*♦. Journal of Biological Chemistry, 292(13), 5610-5621.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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